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Reaction mass of bis(polysubstituted hexanoic acid) bis(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl) diphosphate and bis(polysubstituted hexanoic acid) 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl phosphate and polysubstituted hexanoic acid bis(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl) hydrogen diphosphate and polysubstituted hexanoic acid bis(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl) phosphate and polysubstituted hexanoic acid 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl hydrogen phosphate
EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
The acute oral LD50 in the rat was >5000 mg/kg/bw. The dose for each rat was corrected for percent solids. Therefore, the substance does not need to be classified for acute oral toxicity according to the EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008. The classification of the active component is best described as GHS Category 3 for acute toxicity (inhalation) based on the observed lethality in 3/6 rats at a measured dry solids concentration of 700 mg/m3 (representing the fluorinated, active component without water). An LC50 could not be derived from the available data however; the 700 mg/m3 total concentration of the active approximates an LC50. A single 4-hour exposure of rats to an aerosol of the active was associated with degenerative changes in both the larynx and lungs of exposed rats. The nature of the laryngeal injury (as minimal focal necrosis and inflammation of the ventral larynx at the base of the epiglottis) is commonly seen in rats inhaling irritant substances. While this lesion might be ascribed to a species specific response, based on the presence of necrosis (with ulceration in occasional animals) the laryngeal changes were considered to be adverse. Further, the pulmonary lesions were characterized by haemorrhage and inflammation (mostly neutrophils) within alveoli, thickening of alveolar septa by inflammatory cell infiltrates (mostly neutrophils) and perivascular inflammation. These lesions were considered to be adverse based on the increased severity and incidence of these findings at 98 mg/m3 (0.098 mg/L) relative to controls. Both laryngeal and pulmonary changes were reversible over a 2-week recovery period. The no observable adverse effect level (NOAEL) was 24 mg/m3. Based on the above findings, the substance is classified as T; R23 (Toxic by inhalation) according to EU Directive 67/548/EEC, Cat 3 (H331; Toxic if inhaled) by EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008, and STOT-SE Cat 1 according to CLP.
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