Registration Dossier
Registration Dossier
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EC number: 259-033-6 | CAS number: 54229-13-9
Endpoint summary
Administrative data
Description of key information
Skin: the substance is not irritating to skin based on an OECD 404 study with rabbits.
Eye: the substance is strongly irritating to eye based on two OECD 405 studies with rabbits. The signs of irritation are not fully reversible within 21 d.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Skin: due to the lack of irritation signs, the substance is not classifiable according to GHS criteria.
Eye: in the key study (high substance purity), severe signs of irritaion occured which were not reversible after 8 d (maximum observation period). However, the GHS classification for Category 1 is "not reversible within 21 d". Since the reversibility after 21 d was not shown in a supporting study (lower substance purity) for cornea opacity, the substance is classifiable according to GHS criteria as Category 1 (damaging eyes, not fully reversible within 21 d).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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