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Diss Factsheets
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EC number: 201-854-9 | CAS number: 88-73-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- : lack of details on test substance; observation period only 24 h instead of 72 h.
- Principles of method if other than guideline:
- Method: According to FDA, Fed.Reg.38, No.187, 1973:
- GLP compliance:
- no
Test material
- Reference substance name:
- 1-chloro-2-nitrobenzene
- EC Number:
- 201-854-9
- EC Name:
- 1-chloro-2-nitrobenzene
- Cas Number:
- 88-73-3
- Molecular formula:
- C6H4ClNO2
- IUPAC Name:
- 1-chloro-2-nitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): o-Nitrochlorbenzol
- Analytical purity: no data
- Impurities (identity and concentrations): no data
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Himalayan
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 1,5 - 2 kg
- Diet: ERKA 8300, Robert Koch oHG, Hamm, Germany
- Water: ad libitum
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- other: undissolved
test substance
Amount applied: 100 mg - Duration of treatment / exposure:
- 24 hour(s)
- Observation period (in vivo):
- 24 hour(s)
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): after 24 hours of application
SCORING SYSTEM:
Draize
TOOL USED TO ASSESS SCORE:
fluorescein
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- of 6 tested animals
- Time point:
- other: 24 hours
- Score:
- 0
- Max. score:
- 3
- Remarks on result:
- other: no readings performed at 48 and 72 h after instillation
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- of 6 tested animals
- Time point:
- other: 24 hour
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- of 6 tested animals
- Time point:
- other: 1, 7, 24 hour(s)
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- of 6 tested animals
- Time point:
- other: 1, 7, 24 hour(s)
- Score:
- 0
- Max. score:
- 4
Any other information on results incl. tables
Eye irritation: Undissolved substance
Animal No. |
Part of the eye |
Observation time |
||
1h |
7h |
24h |
||
1 |
Cornea Iris Conjunctivae Chemosis |
0 0 2 0 |
0 0 0 0 |
0 0 0 0 |
2 |
Cornea Iris Conjunctivae Chemosis |
0 0 1 0 |
0 0 1 0 |
0 0 0 0 |
3 |
Cornea Iris Conjunctivae Chemosis |
0 0 1 0 |
0 0 0 0 |
0 0 0 0 |
4 |
Cornea Iris Conjunctivae Chemosis |
0 0 2 0 |
0 0 1 0 |
0 0 0 0 |
5 |
Cornea Iris Conjunctivae Chemosis |
0 0 1 0 |
0 0 0 0 |
0 0 0 0 |
6 |
Cornea Iris Conjunctivae Chemosis |
0 0 1 0 |
0 0 0 0 |
0 0 0 0 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Under these test conditions it can be assumed that no classification for 1-chloro-2-nitrobenzene is required because no irritating effects were observed after 24 hours. Criteria used for interpretation of results: EU
- Executive summary:
Hoechst AG, 1975
The eye irritation potential of 1 -chloro-2 -nitrobenzene was investigated in 6 Himalyan rabbits according to the FDA guideline (federal register, Vol 38, No. 187, 1973). 100 mg undissolved test substance was applied into the conjunctival sac of one eye of each animal. The eyes were rinsed 24 hours after application of the test substance. The eye irritation reactions were examined and scored using the Draize method 1, 7 and 24h after application. After 1 hour 1 -chloro-2 -nitrobenzene induced slight conjunctival redness in all animals (4/6 score=1 and 2/6 score=2). These effects were reversible within 24 h. The mean scores at 24 h were 0.0 for corneal opacity, iritis, chemosis and conjunctivae in all animals. Therefore no classification according to EU classification criteria is required.
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