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EC number: 616-628-9 | CAS number: 78543-37-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- 1996-02-22
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- potassium dibenzyl phosphate
- EC Number:
- 616-628-9
- Cas Number:
- 78543-37-0
- Molecular formula:
- C14-H14-O4-P.K
- IUPAC Name:
- potassium dibenzyl phosphate
- Test material form:
- solid
- Details on test material:
- Batch 97/8
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River (UK) Ltd, margate, Kent
- Age at study initiation: 8 to 12 weeks of age
- Weight at study initiation: 221 to 238g
- Fasting period before study: fasting overnight the day before the dosing
- Housing: by five by sex in solid floor polypropylene cages furnished with woodflakes
- Diet (e.g. ad libitum): free access exept three or four hour after dosing (rat and mouse, expanded diet N°1, special diets services limited, witham, essex, UK)
- Water (e.g. ad libitum): fre access
- Acclimation period: At lest five days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 °C to 22°C
- Humidity (%): 48% to 63%
- Air changes (per hr): 15 changes per hour.
- Photoperiod (hrs dark / hrs light): 12h continuous light and 12hours darkness
IN-LIFE DATES: From: To: 12 may 1997 to 12 june 1997
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 200 mg/mL
- Amount of vehicle (if gavage): 10 mL
MAXIMUM DOSE VOLUME APPLIED:
10 mL/kg - Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- Range finding study: 1 male and 1 female
Main Study: 5 males and 5 females - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration:
30 minutes, 1h, 2h and 4h the first day and once daily for 14 days
- Frequency of weighing: day 0, 7 and 14
- Necropsy of survivors performed: Gross pathological examination
- Other examinations performed: clinical signs
Results and discussion
- Preliminary study:
- At 2000 mg/kg, there were no deaths, Hunched posture was noted during the day of dosing
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occur
- Clinical signs:
- other: No sign of systemic toxicity were noted during the study
- Gross pathology:
- No abnormality were noted at necropsy
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD 50 of the dibenzyl potassium phosphate was determinated to be greater than 2000 mg/kg.
- Executive summary:
The acute Oral LD50 of Dibenzyl Potassium Phosphate has been determined according to OECD 401 test guideline in compliance with GLP.
The LD50 was determinated to be greater than 2000 mg/kg.
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