Registration Dossier
Registration Dossier
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EC number: 241-045-8 | CAS number: 16969-10-1
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The effect of the test item on the respiration rate of an activated sludge obtained from a sewage treatment system treating predominantly domestic sewage was assessed according to the ISO International Standard 8192 (corresponding to OECD test guideline 209 with minor differences). Activated sludge was exposed for 3 hours to the test item and O2 consumption was followed. Based on the respiration rate inhibition, the following results were obtained: EC20 (30 min) = 57 mg/L; EC50 (30 min) = 241 mg/L; EC20 (180 min) = 59 mg/L; EC50 (180 min.) = 177 mg/L.
In addition, a ready biodegradation study according to OECD Guideline 301F (1992) at a nominal concentration of 100 mg/L was conducted on the test item with a toxicity control group.
The test item was not considered to be inhibitory to the microbial inoculum since the biodegradation observed in the toxicity control bioreactor was not less than 25% occurred within 14 days. Therefore, the concentration of 100mg/L test material (nominal) can be considered to be the NOEC for this test system. This endpoint was used as a worst-case conservative approach for PNEC derivation.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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