Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 289-124-6 | CAS number: 86014-76-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
analogue substance 1, EU B1, oral, LD50 > 2000 mg/kg
analogue substance 2, OECD 401, oral LD50 > 2200 mg/kg
other reported studies are with realibilaity 4 and are not used for classification nor for derivation of LD50 parameters
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- Lack of exposure concentrations, only indication of mortality and necropsy findings after exposure time.
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- no details on study desgin and doses. Only qualitative considerations
Additional information
Acute toxicity was assessed mainly through oral route on the target and analogue substance 2. Other exposure patterns ( dermal, inhalation and intraperitoneal) are used only for qualititative considerations.
Acute toxicity: oral
Two studies were considered in order to complete the assessment on Acute oral toxicity: One test was conducted on the substance itself but limited information is available regarding the method and the experimental results. Therefore, another test conducted on the Similar Substance 02 was considered in order to confirm the results of the first test.
The two results are consistent (LD50 > 10000 mg/kg bw and LD50 > 2200 mg/kg bw) and the substance is expected to have an LD50 > 2000 mg/kg bw.
Acute toxicity: inhalation
No deaths occurred at the highest exposure time of 8 hours, however, no indication regarding the exposure concentration was present. For this reason, the performed study is not suitable for classification purpose.
Acute toxicity: dermal
Rats were exposed to a single dermal application of the test substance. After 14 days of observation, no deaths occurred and no abnormalities were noted at necropsy.
Other sudies are available on another route of exposure (intraperitoneal) and were reported in the endpoint nevertheless, no indication on classification can be derived.
Justification for classification or non-classification
According to the CLP Regulation (EC n. 1272/2008) the following classifications apply:
For Acute toxicity oral route:
Category 1: ATE <= 50 mg/kg bw
Category 2: 50 < ATE <= 200 mg/kg bw
Category 3: 200 < ATE <= 1000 mg/kg bw
Category 4: 1000 < ATE <= 2000 mg/kg bw
The LD50 of the test substance was determined to be > 2000 mg/kg bw in the chosen reference test, which is outside the above criteria. Therefore, the test substance is not classified for Acute toxicity by oral exposure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.