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EC number: 200-926-7 | CAS number: 76-02-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Report date: 9 April 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Purity of the test material is not indicated and the study was performed under occlusive conditions.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Report date: 9 April 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Purity of the test item is not indicated.
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: IFFA CREDO breeding center
- Females nulliparous and non-pregnant: no data
- Age at study initiation: no data
- Weight at study initiation: 160 - 200 g
- Fasting period before study: yes, during 17 - 20h
- Housing: Cage of dimensions 37.5 x 23.5 x 16 cm (by 2 or 5) with litter of sterilized and dusted sawdust
- Diet: ad libitum, IFFARAT food
- Water: ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 1°C
- Humidity (%): 50 ± 10%
- Air changes (per hr): 8 per hour
- Photoperiod (hrs dark / hrs light): no data
IN-LIFE DATES: no data - Route of administration:
- oral: gavage
- Vehicle:
- arachis oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 100 mg/mL
- Amount of vehicle (if gavage): 10 - 18 mL/kg
- Justification for choice of vehicle: no data
- Lot/batch no.: no data
- Purity: no data
MAXIMUM DOSE VOLUME APPLIED: 18 mL/kg
DOSAGE PREPARATION: The test material is dissolved in the vehicle.
- Doses:
- 1000, 1200, 1500, 1600 and 1800 mg/kg
- No. of animals per sex per dose:
- 5 males and 5 females per dose
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical observations were performed on all animals at 1, 2, and 6 hours after dosing and on Days 1, 2, 4, 7 and 14. The body weight was recorded on Days 0, 1, 2, .4, 7 and 14.
- Necropsy of survivors performed: no - Statistics:
- Yes, Probit method, Litchfield and Wilcoxon method and Arcsinus method
- Preliminary study:
- 3 groups of 4 animals (2 males and 2 females) received by oral route the test material at these doses: 1000, 2500 and 5000 mg/kg after a fasting period of 18 hours.
The test material is dissolved in arachis oil at a concentration of 25%.
The animals was observed and the mortality was recorded after the treatment and during the 14 days after the treatment.
At 2500 and 5000 mg/kg, all animals died on Day 0. And at 1000 mg/kg, 1 animal died on Day 1. - Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 643 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 1 552 - < 1 740
- Mortality:
- At 1000 and 1200 mg/kg, there was no mortality.
At 1500 mg/kg, one female died and the autopsy revealed hemorrhagic lesions onto lungs and stomach.
At 1600 mg/kg, 4 females died between Day 1 and 2 and one male at Day 12. At the autopsy, animals presented hemorrhagic lesions onto lungs and stomach. For the male died at Day 12, the autopsy revealed that the stomach was joint to the peritoneum, kidney were granular and hemorrhagic aspect, thymic involution.
At 1800 mg/kg, 8 animals died. Autopsies revealed hemorrhagic stomach, lungs and thymus. - Clinical signs:
- other: At 1000, 1200 mg/kg and 1500 mg/kg, 1 to 6 hours after treatment animals presented prostation, apathy, and had a reduce spontaneous activity. At day 1, all the animals exposed at doses of 1000 and 12000 mg/kg presented no abnormalities, but apathy and pr
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- In these test conditions, the acute oral LD50 value of Trichloroacetyl chloride was 1643 mg/kg according to Probit method or Litchfield and Wilcoxon method.
- Executive summary:
The study was performed to assess the acute oral toxicity of Trichloroacetyl chloride (TCAC) in the rat. The method followed was similar to the OECD Guideline 401 and the study was not performed in accordance with GLP.
TCAC was administered to five Sprague-Dawley rats of each sex. The animals were exposed to single oral dose levels of 1000, 1200, 1500, 1600 and 1800 mg/kg. All animals were subjected to observations and determination of body weight. Macroscopic examination was performed on the day of death. At 1800 mg/kg, 8 animals died. Autopsies revealed hemorrhagic stomach, lungs and thymus. At 1600 mg/kg, 4 females died between Day 1 and 2 and one male at Day 12. At the autopsy, animals presented hemorrhagic lesions onto lungs and stomach. For the male died at Day 12, the autopsy revealed that the stomach was joint to the peritoneum, kidney were granular and hemorrhagic aspect, thymic involution. At 1500 mg/kg, one female died and the autopsy revealed hemorrhagic lesions onto lungs and stomach. At 1000 and 1200 mg/kg, there is no mortality.
The acute oral LD50 value of TCAC was 1643 mg/kg according to Probit method or Litchfield and Wilcoxon method.
In these test conditions, TCAC is classified harmful if swallowed according to the UN GHS and CLP criteria.
Table 1: Cumulated mortality
Administration |
Animals |
Cumulated mortality |
|||||||||||
Dose mg/kg |
Volume mL/kg |
Concentration % |
Weight g |
Number |
1 hour |
2 hours |
6 hours |
1 day |
2 days |
4 days |
7 days |
14 days |
% |
Control |
18 |
Arachis oil |
M 156 |
5 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
F 150 |
5 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
||||
1000 |
10 |
10 |
M 155 |
5 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
F 155 |
5 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
||||
1200 |
12 |
10 |
M 152 |
5 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
F 150 |
5 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
||||
1500 |
15 |
10 |
M 156 |
5 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
10 |
F 151 |
5 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
||||
1600 |
16 |
10 |
M 176 |
5 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
50 |
F 168 |
5 |
0 |
0 |
0 |
3 |
4 |
4 |
4 |
4 |
||||
1800 |
18 |
10 |
M 155 |
5 |
0 |
0 |
0 |
2 |
3 |
4 |
4 |
4 |
80 |
F 148 |
5 |
0 |
0 |
0 |
3 |
4 |
4 |
4 |
4 |
LD50 according to:
- Probit: 1643 mg/kg (1566 – 1723 mg/kg)
- Litchfield & Wilcoxon: 1643 mg/kg (1552 – 1740 mg/kg)
- Arcsinus: 1647 mg/kg (1577 – 1721 mg/kg)
Table 2: Body weight gain
a) Males
Sex |
Dose mg/kg |
|
Mean body weight (g) |
|||||
|
Day 0 |
Day 1 |
Day 2 |
Day 4 |
Day 7 |
Day 14 |
||
Males |
Control |
n m s |
5 156 3.11 |
5 174 2.88 |
5 178 2.51 |
5 194 4.09 |
5 217 3.42 |
5 259 10.09 |
1000 |
n m s t |
5 155 5.94 - 0.40 |
5 150 7.06 - 6.81* |
5 164 5.77 - 4.69* |
5 179 8.47 - 3.71* |
5 203 6.76 - 4.13* |
5 258 13.39 - 0.21 |
|
1200 |
n m s t |
5 152 6.86 - 1.13 |
5 145 6.46 - 9.16* |
5 153 7.69 - 6.85* |
5 169 7.09 - 6.99* |
5 191 6.80 - 7.57* |
5 251 10.94 - 1.29 |
|
1500 |
n m s t |
5 156 2.86 0.21 |
5 149 4.60 - 10.04* |
5 153 6.40 - 7.80* |
5 171 3.96 - 9.04* |
5 193 4.56 - 9.65* |
5 255 17.21 - 0.79 |
|
1600 |
n m s t |
5 176 / / |
5 157
|
5 157
|
5 170
|
5 161
|
4 250
|
|
1800 |
n m s t |
5 155 / / |
3 139
|
2 137
|
1 163
|
1 184
|
1 250
|
b) Females
Sex |
Dose mg/kg |
|
Mean body weight (g) |
|||||
|
Day 0 |
Day 1 |
Day 2 |
Day 4 |
Day 7 |
Day 14 |
||
Females |
Control |
n m s |
5 150 3.77 |
5 166 2.49 |
5 169 2.19 |
5 181 1.87 |
5 187 1.14 |
5 221 6.23 |
1000 |
n m s t |
5 155 4.72 1.63 |
5 155 5.22 - 5.49* |
5 164 7.09 - 1.75 |
5 177 4.22 - 2.13 |
5 187 5.10 - 0.17 |
5 215 8.00 0.57 |
|
1200 |
n m s t |
5 150 6.50 0.00 |
5 137 3.63 - 14.72* |
5 147 10.42 - 4.71* |
5 164 6.40 - 5.70* |
5 178 6.12 - 3.37* |
5 205 6.11 - 1.79 |
|
1500 |
n m s t |
5 151 6.46 0.18 |
5 141 7.16 - 7.19* |
4 149 17.39 - 2.71* |
4 163 17.52 - 2.39* |
4 181 15.46 - 0.98 |
4 212 21.28 - 1.52 |
|
1600 |
n m s t |
5 168 / / |
2 148
|
1 147
|
1 181
|
1 194
|
1 215
|
|
1800 |
n m s t |
5 148 / / |
2 137
|
1 153
|
1 168
|
1 185
|
1 212
|
n: number of survivors
m: mean
s: standard deviation
*: significant test t at the threshold of 95%
/: no information on this sigle in the report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- occlusive conditions.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Test material form:
- liquid
- Details on test material:
-
Name of the test material in the report: Chlorure de trichloracetyle
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: IFFA CREDO breeding center
- Females nulliparous and non-pregnant: no data
- Age at study initiation: no data
- Weight at study initiation: 165 - 172 g
- Fasting period before study: yes, during 17 - 20h
- Housing: Cage of dimensions 37.5 x 23.5 x 16 cm (by 2 or 5) with litter of sterilized and dusted sawdust
- Diet: ad libitum, IFFARAT food
- Water: ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 1°C
- Humidity (%): 50 ± 10%
- Air changes (per hr): 8 per hour
- Photoperiod (hrs dark / hrs light): no data
IN-LIFE DATES: no data
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: no data
- % coverage: no data
- Type of wrap if used: bandage consisting of a sheet of aluminum foil and strip of adhesive tape
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 1.23 mL/kg
- Concentration (if solution): prodcut as is
- Constant volume used: yes - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 10 (5 males and 5 females)
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations (mortality and behaviour) and weighing: Clinical observations were performed on all animals at 1, 2, and 6 hours after dosing and on Days 1, 2, 4, 7 and 14. The body weight was recorded on Days 0, 1, 2, .4, 7 and 14.
- Necropsy of survivors performed: no - Statistics:
- Yes, Probit method, Litchfield and Wilcoxon method and Arcsinus method
Results and discussion
- Preliminary study:
- 2 groups of 4 animals (2 males and 2 females) received by dermal route the test material at these doses: 1000 and 2000 mg/kg (volume: 0.62 and 1.23 mL/kg, respectively). The test material was applied as such.
The animals were observed and the mortality was recorded after the treatment and during the 14 days after the treatment.
At 1000 and 2000 mg/kg, there was no mortality.
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred at the dose level of 2000 mg/kg.
- Clinical signs:
- other: There was no clinical sign.
- Gross pathology:
- Macroscopic examination of the main organs of the animals revealed no apparent abnormalities except cutaneous reactions (see below).
- Other findings:
- Local tolerance:
Day 1: Increase of dermal thickness on application site.
Day 4: Skin lesions on the back of animals.
Day 7: purulent lesions.
Day 14: persistence of skin lesions.
Any other information on results incl. tables
Table 1: Mortality
Administration |
Animals |
Cumulated mortality |
|||||||||||
Dose mg/kg |
Volume mL/kg |
Concentration % |
Weight g |
Number |
1 hour |
2 hours |
6 hours |
1 day |
2 days |
4 days |
7 days |
14 days |
% |
Control |
- |
- |
M 168 |
5 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
F 165 |
5 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
||||
2000 |
1.23 |
Product as such |
M 172 |
5 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
F 171 |
5 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Table 2: Body weight gain
Sex |
Dose mg/kg |
|
Mean body weight (g) |
|||||
|
Day 0 |
Day 1 |
Day 2 |
Day 4 |
Day 7 |
Day 14 |
||
Males |
Control |
n m s |
5 168 5.15 |
5 153 7.92 |
5 165 4.27 |
5 180 5.45 |
5 210 4.76 |
5 264 6.60 |
2000 |
n m s t |
5 172 7.95 0.90 |
5 157 8.76 0.68 |
5 161 8.99 1.03 |
5 172 11.20 - 1.47 |
5 198 8.57 - 2.78* |
5 238 11.48 - 4.45* |
|
Females |
Control |
n m s |
5 165 6.38 |
5 161 8.58 |
5 166 7.89 |
5 176 7.23 |
5 193 6.88 |
5 217 4.44 |
2000 |
n m s t |
5 171 7.40 1.37 |
5 162 7.40 0.20 |
5 161 6.80 - 1.11 |
5 171 10.90 - 0.72 |
5 190 12.84 - 0.58 |
5 213 9.52 - 0.85 |
n: number of survivors
m: mean
s: standard deviation
*: significant test t at the threshold of 95%
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- In these test conditions, the acute dermal LD50 value of Trichloroacetyl chloride was found to be higher to 2000 mg/kg.
- Executive summary:
The study was performed to assess the acute dermal toxicity of Trichloroacetyl chloride (TCAC) in the rat. The method followed was similar to OECD Guideline 402 and the study was not performed in accordance with GLP.
Ten animals (5 males and 5 females) were exposed to single dermal dose level of 2000 mg/kg. All animals were subjected to observations and determination of body weight. Macroscopic examination was performed after terminal sacrifice. No mortality occurred at the dose level of 2000 mg/kg and there was no clinical sign. Macroscopic examination of the main organs of the animals revealed no apparent abnormalities except cutaneous reactions (Day 7: purulent lesions - Day 14: persistence of skin lesions).
The acute dermal LD50 value of TCAC was higher to 2000 mg/kg.
In these test conditions, TCAC is not classified according to the UN GHS and CLP criteria.
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