4-chloro-2,5-dimethoxyaniline

Boiling point

Administrative data

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2010-06-02 to 2010-07-29

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Recent, well documented GLP and guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2010

Report date:

2010

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling point/boiling range)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Test material

Test material information

Constituent 1

Reference substance name:

4-chloro-2,5-dimethoxyaniline

EC Number:

228-782-0

EC Name:

4-chloro-2,5-dimethoxyaniline

Cas Number:

6358-64-1

Molecular formula:

C8H10ClNO2

IUPAC Name:

4-chloro-2,5-dimethoxyaniline

Results and discussion

Boiling point

Decomposition:

yes

Decomp. temp.:

222 °C

Any other information on results incl. tables

RESULTS OF THE DIFFERENTIAL SCANNING CALORIMETRY

In both tests the anticipated endothermal water-evaporation peak at approximately 100°C and the endothermal melting peak with an onset-temperature of approximately 117 °C were detected.

A further endothermal event, which would indicate boiling of the test item, was not detected. At approximately 200°C an exothermal drift in the baseline of the DSC thermogram was observed. This drift was followed by a significant exothermal decomposition of the test item with an onset-temperature of 222°C (495 K).

The measured temperatures are summarized in the following table.

RESULTS OF THE DIFFERENTIAL SCANNING CALORIMETRY

	1s^ttest	2^ndtest
Amount of test substance [mg]	8.76	12.76
Start temperature [°C]	30	30
Heating rate [K/min]	5	5
End temperature [°C]	500	500
Onset temperature of the endothermal water-evaporation peak [°C]	100	101
Onset temperature of the endothermal melting peak [°C]	117	117
Start of exothermal drift of the base line, indicating start of decomposition	200	200
Onset temperature of theexothermal decomposition[°C]	222	222
Mean decomposition temperature	222°C / 495 K

Applicant's summary and conclusion

Conclusions:

Based on the available thermograms (see pages 8 and 9 of full study report) it can be stated,
that the test item 4-Chloro-2,5-dimethoxyaniline has no boiling point.
It decomposed exothermally at a temperature of 222°C.

Executive summary:

Based on the available thermograms (see pages 8 and 9 of full study report) it can be stated, that the test item 4-Chloro-2,5-dimethoxyaniline has no boiling point. It decomposed exothermally at a temperature of 222°C.