Registration Dossier
Registration Dossier
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EC number: 226-420-6 | CAS number: 5397-31-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: basic information given
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 963
- Report date:
- 1963
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-(2-ethylhexyloxy)propylamine
- EC Number:
- 226-420-6
- EC Name:
- 3-(2-ethylhexyloxy)propylamine
- Cas Number:
- 5397-31-9
- Molecular formula:
- C11H25NO
- IUPAC Name:
- 3-[(2-ethylhexyl)oxy]propan-1-amine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: "Heigl" rats
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: aqueous traganth
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 2, 8, 20% (v/v) - Doses:
- 0.2, 0.4, 0.8 and 1.6 mL/kg bw (0.169, 0.338, 0.676 and 1.352 mg/kg bw) - conversion in mg/kg bw is based on density of test substance (0.845 g/mL)
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 845 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: original value: ca. 1.0 mL/kg bw
- Mortality:
- 0.2 and 0.4 mL/kg bw: no deaths after 7 days
0.8 mL/kg bw: 2/5 after 7 days
1.6 mL/kg bw: 5/5 after 7 days - Clinical signs:
- other: Animals that died showed 20 minutes after administration spasmodic trembling, tonic-clonic convulsions and breathlessness. The surviving animals recovered soon. Already on the evening of the study day no remarkable symptoms were seen.
- Gross pathology:
- Animals that died: reddening of the gastric mucosa
Sacrificed animals: Organs mainly without findings
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
