Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 225-184-1 | CAS number: 4702-90-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
- Principles of method if other than guideline:
- Internal BASF method was used. A 50% aqueous preparation of the substance has been applied on the back and ear of rabbits for 20 hours, observations were reported after 24h, 48h, 5 days, 6 days 7 days and 8 days.
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one
- EC Number:
- 225-184-1
- EC Name:
- 4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one
- Cas Number:
- 4702-90-3
- Molecular formula:
- C21H18N4O2
- IUPAC Name:
- 4,4'-methylylidenebis(5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one)
- Details on test material:
- - Physical state: solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: male 2.76 kg, female 3.03 kg
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Concentration (if solution): 50% - Duration of treatment / exposure:
- 20 h
- Observation period:
- 24 h, 48 h, 5 d, 6 d, 7 d, 8 d
- Number of animals:
- 2
- Details on study design:
- TEST SITE
- Area of exposure: back of animals
- Type of wrap if used: 2.5x2.5cm cotton lint moistened with test substance
REMOVAL OF TEST SUBSTANCE
- Washing (if done): with water
- Time after start of exposure: 20 h
SCORING SYSTEM:
The original BASF grading was converted into the numerical grading according to the OECD Draize system.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24, 48 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24, 48 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritant / corrosive response data:
- Yellow substance residues were reported.
Any other information on results incl. tables
Animal 1: male, 2.76 kg
Animal 2: female, 3.03 kg
Results:
| Readings | Animal | Erythema | Edema | Additional findings |
| 24 h | 1 | 0 | 0 | s |
| 2 | 0 | 0 | s | |
| 48 h | 1 | 0 | 0 | s |
| 2 | 0 | 0 | s | |
| 5d | 1 | 0 | 0 | s |
| 2 | 0 | 0 | s | |
| 6 d | 1 | 0 | 0 | s |
| 2 | 0 | 0 | s | |
| 7 d | 1 | 0 | 0 | s |
| 2 | 0 | 0 | s | |
| 8 d | 1 | 0.0 | 0.0 | s |
| 2 | 0.0 | 0.0 | s | |
| mean 24 - 72 h | 1 | 0.0 | 0.0 | |
| 2 | 0.0 | 0.0 | ||
| mean | 0 | 0 |
s: substance precipitation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
