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EC number: 203-623-8 | CAS number: 108-86-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13 Nov 1980 - 4 Feb 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- (no GLP, not according to guideline)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- The Effects of Fasting on the Acute Oral Toxicity of Nine Chemicals in the Rat
- Author:
- Dashiell, O.L. and Kennedy, G.L.
- Year:
- 1 984
- Bibliographic source:
- J. Appl. Toxicol. 4(6):320-325
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Principle of test: Single oral dose administration of three doses of bromobenzene administered to fasted and non-fasted rats
- Short description of test conditions: 10 males per dose were treated and observed for 14 - 16 days
- Parameters analysed / observed: mean time of death, clinical signs, mean body weight change from day 1 to 14, LD50 - GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Bromobenzene
- EC Number:
- 203-623-8
- EC Name:
- Bromobenzene
- Cas Number:
- 108-86-1
- Molecular formula:
- C6H5Br
- IUPAC Name:
- bromobenzene
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source of test material: Fischer Chemicals, Fairlawn, NJ, USA
Test animals
- Species:
- rat
- Strain:
- other: Crl-CD
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Laboratory, North Wilmington, MA, USA
- Age at study initiation: Approx. 60 days
- Weight at study initiation: 220 - 280 g
- Fasting period before study: Yes, groups of fasted (24 h) and non-fasted animals were dosed
- Diet: Purina Rat Chow (Ralston Purina Co., St Louis, USA), ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 10 - 25%
MAXIMUM DOSE VOLUME APPLIED: 4.5 mL
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: Dose levels were selected based on a range-finding study to deine a dose producing mortality. - Doses:
- fasted animals: 2000, 2800 and 3500 mg/kg
non-fasted: 3000, 3500 and 4000 mg/kg - No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 - 16 days
- Frequency of weighing: Individual body weights were determined on Days 0, 1 and 14
- Necropsy of survivors performed: no
- Other examinations performed: mortality, clinical signs, body weight - Statistics:
- LD50 values were determined by Probit analysis (Finney, 1971).
Results and discussion
- Preliminary study:
- One rat was treated with 670 - 7500 mg/kg bw to roughly define the dose producing mortality. Mortality was observed starting at 3400 mg/kg bw.
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3 591 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: non-fasted rats
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 383 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: fasted rats
- Mortality:
- Fasted animals
2000 mg/kg: 3/10 animals died
2800 mg/kg: 6/10 animals died
3500 mg/kg: 10/10 animals died
Non-fasted animals
3000 mg/kg: 1/10 animals died
3500 mg/kg: 4/10 animals died
4000 mg/kg: 8/10 animals died - Clinical signs:
- other: Fasted animals All doses: stained and wet perineal area, stained face, lacrimation, chromodacryorrhea, diarrhea and congestion 2000 mg/kg: weakness 2800 mg/kg: weakness, lethargy, prostration 3500 mg/kg: salvation, tremors, prostration Non-fasted animals
- Gross pathology:
- Not performed
Any other information on results incl. tables
Table 1: Results of acute oral toxicity study
Dose [mg/kg] |
Mortality |
Day of deatha |
Weight decrease day 0-1 [g]a |
Weight increase day 0-14 [g]a |
Fasted |
|
|
|
|
2000 |
3 |
2 ± 1 |
7 ± 2 |
36 ± 4 |
2800 |
6 |
2 ± 1 |
8 ± 1 |
40 ± 2 |
3500 |
10 |
2 ± 1 |
5 ± 2 |
- |
Non-fasted |
|
|
|
|
3000 |
1 |
3 ± 0 |
11 ± 3 |
17 ± 4 |
3500 |
4 |
2 ± 1 |
9 ± 4 |
16 ± 4 |
4000 |
8 |
3 ± 2 |
12 ± 2 |
20 ± 3 |
a: mean ± SD
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation(EC) No. 1272/2008
- Conclusions:
- CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No 1272/2008
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