Registration Dossier
Registration Dossier
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EC number: 200-891-8 | CAS number: 75-68-3
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
A GLP-compliant OECD 202 guideline test was available the 48-h EC50 value of 1-chloro, 1,1-difluoroethane in Daphnia magna is 160 mg/l (Duphar 1990b). Another GLP-compliant OECD 202 guideline test is available (Haskell Laboratory 1989), but the effect concentration was less critical. The value of 160 mg/l is used in the assessment.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 160 mg/L
Additional information
The acute toxicity of 1-chloro, 1,1-difluoroethane was evaluated with Daphnia magna in a study performed in accordance with OECD testing guideline 202 and GLP requirements.
The young daphnids were exposed to nominal test concentrations between 30 and 300 mg/L under static conditions during 48 hours. The mean measured concentrations were maintained between 80 and 120 % of nominal. EC50-48 h was estimated using measured concentrations as being equal to 160 mg/L.
A few deviations of the Guidelines were necessary:
-preparation of test solutions
- the immobile daphnids were not removed after 24 because the flasks had to remain closed to avoid
disappearence of the substance.
- the pH and dissolved oxygen concentrations were
measured in the ISO-water only and not in the
tests substance for the same reason
These deviations did not influence the results of the study
The control mortality was higher than expected. A few daphnids were sticked between the water level and the rubber septum at test termination, caused by the method used to minimise the evaporation of the test material. No other abnormalities were observed after 48 hours.
A GLP-compliant OECD 202 guideline test was available the 48-h EC50 value of 1-chloro, 1,1-difluoroethane in Daphnia magna is 160 mg/l (Duphar 1990b). Another GLP-compliant OECD 202 guideline test is available (Haskell Laboratory 1989), but the effect concentration was less critical. The value of 160 mg/l is used in the assessment.
Based on these results, 1-Chloro,1,1-difluoroethane is of low toxicity to daphnids.
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