Registration Dossier
Registration Dossier
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EC number: 231-149-1 | CAS number: 7440-39-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Remarks:
- Waiver for pH/corrosivity effects
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- the study need not be conducted because the available information indicates that the criteria are met for classification as corrosive to the skin or irritating to eyes
- the study need not be conducted because the substance is a strong acid (pH <= 2.0) or base (pH => 11.5)
- Justification for type of information:
- Justification for type of information: Barium metal reacts with water to form the hydroxide Ba(OH) 2, which is a strong base that dissociates completely into Ba2+and OH- ions, with resulting high pH level in solution (pH> 11 at 1 mM). Because barium metal reacts with water into barium dihydroxide and thus into a strong base, studies on skin and eye irritation should not be conducted: for this reason, barium (because of its reactivity and formation of barium dihydroxide) meets the classification criteria of Regulation (EC) no 1272/2008 for Skin Corrosion Category 1 (H314: causes severe skin burns and eye damage) and Eye Damage Category 1 (H318: Causes serious eye damage).
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Barium metal reacts with water to form the Ba(OH)2, which is a strong base that dissociates completely into Ba2+ and OH- ions, with resulting high pH level in solution (pH> 11 at 1 mM).Because barium metal reacts with water into barium dihydroxide and thus into a strong base, studies on skin and eye irritation should not be conducted: for this reason, barium (because of its reactivity and formation of barium dihydroxide) meets the classification criteria of Regulation (EC) no 1272/2008 for Eye damage Category 1 (H318: Causes serious eye damage).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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