Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 217-978-1 | CAS number: 2028-63-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- April 1967
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
- Report date:
- 1967
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test substance was i.p. injected into mice.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- But-3-yn-2-ol
- EC Number:
- 217-978-1
- EC Name:
- But-3-yn-2-ol
- Cas Number:
- 2028-63-9
- Molecular formula:
- C4H6O
- IUPAC Name:
- but-3-yn-2-ol
- Details on test material:
- purity 56.1%
other component: water
according to order sheet from Dec 2nd 1988
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: "Kisslegg" mice
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Details on exposure:
- Form of application: solution
Concentrations used: 0.5 and 1 % (w/v) (1 % was used for 100 mm3/kg bw) - Doses:
- 25, 50, 64, 80 and 100 mm3/kg
30, 59, 76, 95 and 119 mg/kg bw (calculated based on density at 20 °C = 1.189) - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- No data
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 71 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: original value: LD50 ca. 60 mm3/kg bw, mg/kg bw calculated based on density at 20 °C = 1.189
- Mortality:
- Animals that died:
25 mm3/kg bw: 1 h: 0/10; 24 h: 0/10; 48 h: 0/10; 7 d: 0/10
50 mm3/kg bw: 1 h: 0/10; 24 h: 1/10; 48 h: 1/10; 7 d: 1/10
64 mm3/kg bw: 1 h: 0/10; 24 h: 2/10; 48 h: 4/10; 7 d: 5/10
80 mm3/kg bw: 1 h: 0/10; 24 h: 10/10; 48 h: 10/10; 7 d: 10/10
100 mm3/kg bw: 1 h: 0/10; 24 h: 10/10; 48 h: 10/10; 7 d: 10/10 - Clinical signs:
- In animals with high dose treatment dyspnea, apathy, seizures and hypothermia were detected. Animals treaten with 64 mm3/kg bw and lower showed only slight symptoms and some recovered.
- Body weight:
- Only recorded before application.
- Gross pathology:
- Partly fatty metamorphosis of the liver was detected in 7 of the animals that died after treatment and 2 sacrifised after 7 days.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.