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EC number: 226-749-5 | CAS number: 5462-06-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Abiotic degradation:
Air:
No experimental data on the phototransformation of the substance in air are available. Based on estimation with the QSAR model AopWin (v1.92), in air the substance undergoes rapid degradation after reaction with hydroxyl radicals. The DT50-values after reaction with hydroxyl radicals are 7.164 hours. This indicates that the substance is not a long-range transported chemical in air according to the UNECE criteria (http://www.unece.org/fileadmin/DAM/env/documents/2000/ece/eb/ece%20eb%20air.60.e.pdf). This half-live will not be used for the CSA because these are calculated and not experimental values.
Water:
The hydrolysis test for this substance is not needed because of its ready biodegradability. The substance is expected to be hydrolytically stable because it does not contain hydrolysable groups such as ester, carbamates, epoxides, halomethanes, acylhalides (see Hydrowin, EpiSuite for all hydrolysable groups). The half-life at 25 °C is > 1 year.
Biotic degradation:
The biodegradation potential of the substance in water was determined in a screening study according to OECD TG 301F (Manometric Respirometry) and in compliance with GLP criteria. In this study 30 mg/L test substance was inoculated with activated sludge from a municipal wastewater treatment plant for 30 days under aerobic conditions in the dark. During the incubation period the biological oxygen demand (BOD) was measured and biodegradation expressed as percentage of the theoretical uptake (ThOD). After the 28-day incubation period 81% of the substance was biodegraded. The 10-day window criterion was met. Based on these findings, the test substance is classified as readily biodegradable.
Bioaccumulation:
The BCFs for aquatic and terrestrial organisms were calculated using QSARs of Veith et al. (1979) and Jager (1998), both incorporated in the EUSES model, and yielded values of 18 and 3.23 L/kg ww, respectively.
Transport and distribution:
The adsorption/desorption test does not need to be conducted as based on the physico-chemical properties, the substance can be expected to have a low potential for adsorption (log Kow is 2.3). Therefore, the organic carbon-water partitioning coefficient (Koc) was calculated from the log Kow using the equation from EUSES (non-hydrophobics QSAR, because the log Kow < 3). The calculated Koc value is 164 L/kg (log Koc = 2.21). This Koc-value indicates that the substance has a low potential to adsorb to sediment/soil.
The Henry's law constant is calculated using the equation from EUSES. Using a molecular weight of 178.23 g/mol, and the experimentally determined vapour pressure of 0.30 Pa (at 24 °C) and water solubility of 1085.7 mg/L (at 24 °C) the Henry's law constant at environmental temperature (12 °C) is calculated to be 0.0249 Pa·m³/mol.
Based on Level III environmental distribution modelling using EPISUITE (assuming equal and continuous releases to air, water and soil) using the CAS number 5462-06-6 and the measured physicochemical parameters (water solubility = 1085.7 mg/L, vapour pressure = 0.0024 mg Hg and log Kow = 2.3) as input, it is estimated that the majority of the substance released to the environment will partition mainly into soil (68.1%) and water (31.4%) with minor amounts to air (0.392%) and sediment (0.116%).
The SimpleTreat model, which is incorporated in EUSES, simulates the distribution of the substance in a Sewage Treatment Plant (STP). Model calculations show that 86% of the substance will be degraded and that 12.5%, 1.52% and 0.00992% will partition to water, sewage sludge and air, respectively.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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