Registration Dossier
Registration Dossier
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EC number: 635-476-4 | CAS number: 88349-88-6
Endpoint summary
Administrative data
Description of key information
The hydrolytic stability of [14C]-cloquintocet acid was studied in buffered aqueous solution, under sterile conditions, at pH values of 4, 7 and 9. Solutions of aqueous buffers were prepared at pH 4, 7 and 9 at ca 50°C.
At 50°C, cloquintocet acid was hydrolytically stable at pH 4, 7 and 9 after incubation for 5 days with > 95% of applied radioactivity recovered as unchanged cloquintocet acid. In accordance with the guideline 10% hydrolysis at 50°C over 5 days corresponds to a DT-50 of more than a year at 25°C and for substances that hydrolyse less than this, no further testing is required.
The UV/VIS spectral absorption of cloquintocet acid was determined. These data were used for calculation of the half lives of direct photochemical degradation under environmental conditions for the months March and June in Central Europe.
The absorption maxima was at 313.5 nm and decadic molar extinction coefficient was Ɛ = 3842 [l/mol/cm]at 321 nm for cloquintocet acid, respectively.
Assuming a quantum yield for the direct photolytic degradation of 1.0, half lives were calculated to be 2 minutes (March) and 1 minute (June) for cloquintocet acid. Applying a quantum yield of only 0.1, corresponding half lives for cloquintocet acid would be between 22 and 6 sunlight minutes which would mean a very rapid degradation by direct photolysis in all seasons. As a worst-case, the value of 22 minutes was chosen as the key value from the study.
No further stability tests were conducted as they are not required under REACH Annex VIII.
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