4,7-dimethyloct-6-en-3-one

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

The study was conducted in 1972.

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1972

Report date:

1972

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

Deviations:

no

Principles of method if other than guideline:

Irritation study in rabbits. Test material in Neantin was applied to the skin of the rabbits for 24 hours at several different concentrations: 100%, 30%, 10%, 3% and 1%. Irritation effects were observed for a period of 7 days. A second study was conducted with repeated applications at 10%, 3% and 1% each day for 7 consecutive days.

GLP compliance:

no

Remarks:

pre-dates GLP

Test material

Test material information

Constituent 1

Reference substance name:

4,7-dimethyloct-6-en-3-one

EC Number:

219-845-3

EC Name:

4,7-dimethyloct-6-en-3-one

Cas Number:

2550-11-0

Molecular formula:

C10H18O

IUPAC Name:

4,7-dimethyloct-6-en-3-one

Test material form:

liquid

Test animals

Species:

rabbit

Strain:

not specified

Details on test animals or test system and environmental conditions:

No data

Test system

Type of coverage:

occlusive

Preparation of test site:

not specified

Vehicle:

other: Neantin

Controls:

yes, concurrent vehicle

Amount / concentration applied:

100%, 30%, 10%, 3% and 1%

Duration of treatment / exposure:

24 hours

Observation period:

7 days

Details on study design:

Klecak, 1970

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

24/48 h

Score:

2

Max. score:

3

Reversibility:

fully reversible within: 7 days

Results 2

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

72 h

Score:

1

Max. score:

3

Reversibility:

fully reversible within: 7 days

Results 3

Irritation parameter:

overall irritation score

Remarks:

single application

Basis:

mean

Time point:

7 d

Score:

0

Max. score:

3

Irritant / corrosive response data:

Study 1
3 % irritant effects weak irritation was observed on day 1 only. Scores were normal on days 2 thru 7.
30 % irritant effects irritation and secretion was observed on day 1. Weak irritation was observed on day 2, 3 and 4. Scores were normal on days 5 thru 7.
100 % irritant effects strong irritation and secretion was observed on days 1 and 2. Irritation and secretion was observed on days 3 and 4. Weak irritation was observed on days 5 and 6. Scores were normal on day 7.
Study 2
10 % irritant effects weak irritation was observed on days 1 and 2. Scores were normal on days 3 thru 7.
1 % no effects

Other effects:

Test material in Neantin was applied to the skin of the rabbits for 24 hours at several different concentrations. Irritation effects were observed for a period of 7 days; irritation was initially observed, but was resolved within 7 days at 100% test article concentration.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

Irritation study in rabbits. Test material in Neantin was applied to the skin of the rabbits for 24 hours at concentrations of 1%, 3%, 10%, 30% and 100%. Irritation effects were observed for a period of 7 days. All scores were normal by day 7.

Executive summary:

Irritation study in rabbits. Test material in Neantin was applied to the skin of the rabbits for 24 hours at concentrations of 1%, 3%, 10%, 30% and 100%. Irritation effects were observed for a period of 7 days. All scores were normal by day 7.