1-methylpiperidin-4-ol

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

calculation (if not (Q)SAR)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification

Justification for type of information:

Data is from computational model developed by USEPA

Qualifier:

according to guideline

Guideline:

other: Modeling database

Principles of method if other than guideline:

Data is predicted by ECOSAR v1.1

GLP compliance:

no

Specific details on test material used for the study:

- Name of test material (as cited in study report): 1-methylpiperidin-4-ol
- Molecular formula: C6H13NO
- Molecular weight: 115.175 g/mol
- Substance type: Organic
- Physical state: Liquid

Analytical monitoring:

not specified

Vehicle:

not specified

Test organisms (species):

Daphnia magna

Test type:

static

Water media type:

freshwater

Total exposure duration:

48 h

Hardness:

No data

Test temperature:

No data

pH:

No data

Dissolved oxygen:

No data

Salinity:

No data

Conductivity:

No data

Nominal and measured concentrations:

No data

Details on test conditions:

No data

Reference substance (positive control):

not specified

Key result

Duration:

48 h

Dose descriptor:

LC50

Effect conc.:

3 674.98 mg/L

Nominal / measured:

estimated

Conc. based on:

test mat.

Basis for effect:

mobility

Validity criteria fulfilled:

not specified

Conclusions:

The predicted data by ECOSAR version 1.1, suggests the 48 hr lethal concentration (LC50) for the 4-Piperidinol, 1-methyl- (CAS no106-52-5) to be 3674.980mg/l for Daphnia magna.

Executive summary:

48 hrs aquatic toxicity studies (EPI suite, ECOSAR version 1.1, 2016) were conducted to assess toxic effects of the 4-Piperidinol, 1-methyl- (CAS no106-52-5) and the results were predicted. The study was based on the effects of the test compound on the Daphnia magna in a static fresh water system. The predicted data suggests the lethal concentration (LC50) for the 4-Piperidinol, 1-methyl- (CAS no106-52-5) was estimated to be 3674.980mg/l

Based on the result the 4-Piperidinol, 1-methyl- was considered as not classified to aquatic invertebrates.

Description of key information

The predicted data by ECOSAR version 1.1, suggests the 48 hr lethal concentration (LC50) for the 4-Piperidinol, 1-methyl- (CAS no106-52-5) to be 3674.980mg/l for Daphnia magna.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

3 674.98 mg/L

Additional information

Various predicted studies and read across study for the 4-Piperidinol, 1-methyl-were reviewed to summarize the following information: 

48 hrs aquatic toxicity studies (EPI suite, ECOSAR version 1.1, 2016) were conducted to assess toxic effects of the 4-Piperidinol, 1-methyl- (CAS no106-52-5) and the results were predicted. The study was based on the effects of the test compound on the Daphnia magna in a static fresh water system. The predicted data suggests the lethal concentration (LC50) for the 4-Piperidinol, 1-methyl- (CAS no106-52-5) was estimated to be 3674.980mg/l.

Using similar experimental conditions, 48 hr aquatic toxicity study (SSS QSAR prediction model, 2016) were conducted to assess toxic effects of the4-Piperidinol, 1-methyl- (CAS no106-52-5) and the results were predicted. The study was based on the effects of the test compound on the Daphnia magna in a static fresh water system. The predicted data suggests the effective concentration (EC50) for the4-Piperidinol, 1-methyl- (CAS no106-52-5) was estimated to be 120 mg/L on the basis of intoxication.

A study was performed for read across chemical N-Methyldiethanolamine (105-59-9) as short term toxicity test (IUCLID dataset, European commission – European chemicals bureau,18–FEB–2000) in Daphnia magna for 48 hrs using guideline 79/831/EWG. The EC0, EC 50 and EC100 value in 48 hrs for short term toxicity to aquatic invertebrates for N-Methyldiethanolamine (105 -59 -9) were determined to be 125 mg/l, 230 mg/l and 500 mg/l respectively. Based on the result the N-Methyldiethanolamine was considered as not classified as per CLP regulation.

Another study on same read across cas was performed in Daphnia magna (Sids initial assessment profile, CoCAM2, 17-19 April 2012) for 48 hrs using guideline 79/831/EWG. From the experiment the EC0, EC 50 and EC100 value for short term toxicity to aquatic invertebrates for N-Methyldiethanolamine (105 -59 -9) were determined to be 250 mg/l, 400 mg/l and >500 mg/l. On the basis of result the N-Methyldiethanolamine was considered as not classified.

Based on the results of predicted data for target chemical and read across studies, it can be considered that the 4-Piperidinol, 1-methyl- (CAS No 106-52-5) is not likely to be toxic to aquatic invertebrates at environmentally relevant concentrations and can be considered as not classified as per the criteria of CLP regulation