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Diss Factsheets
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EC number: 206-017-1 | CAS number: 288-13-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In a GLP conform Ames test according to OECD guideline 471 (and former OECD guideline 472), the test substance (purity 99.8%) was tested for gene mutations in Salmonella typhimurium strains TA100, TA1535, TA98, TA1537 and E. coli WP2 uvrA with or without metabolic activation. Here, a standard plate test (SPT) and a preincubation test (PIT) were performed in doses up to 5000 μg/plate in all strains; additionally, TA 1535 was tested up to 8000 µg/plate in the PIT. The test substance was weakly mutagenic in TA 1535 without metabolic activation system under the experimental conditions chosen, however, only in high doses >= 4000 µg/plate. Impurities rather than the test substance itself might be the cause for the effects observed. Therefore, the test substance Pyrazole ist finally considered as not mutagenic in the Ames test.
Another Ames test was performed with rather unconvenient Salmonella strains BA9 and BA13, the so called Ara mutation assay which is supposed to be highly sensitive to a wide variety of mutagens. With and without metabolic activation system, the test substance was not mutagen in doses up to 5000 µg/plate in the SPT and up to 5000 mg/mL in an LT (Duran et al. 1986).
In a further, narrowly described Ames test, the test substance was not mutagenic in S. typhimurium strains TA98, TA100, TA1535, TA1537 and TA1538 with and without metabolic activation system. No further information were given (Walsh and Claxton 1987).
Short description of key information:
in vitro
Gene mutation in bacteria
Ames test, S. typhimurium TA100, TA1535, TA98 and TA1537 and E. coli WP2 uvrA with and without metabolic activation: negative (weakly positive results in high doses were considered as caused by impurities; GLP, OECD 471; Rhone-Poulenc 1996)
Endpoint Conclusion:
Justification for classification or non-classification
The weakly positive result in the most valid Ames test is considered as caused by impurities since the increase of revertants appeared only at high doses. Based on that assessment and further negative results in other Ames tests, there is no indication given for a classification according to 67/548/EEC and GHS requirements, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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