Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 210-789-5 | CAS number: 623-36-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral: The acute oral LD50 was determined to be 4290 mg/kg bw in rats.
Dermal: The acute dermal LD50 was determined to be 4000 mg/kg bw in rabbits.
Inhalation: The acute inhalation LC50 was determined to be 8100 mg/m³ air/4 h in rats.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 4 290 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 8 100 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 4 000 mg/kg bw
Additional information
Oral:
The test article 2-methyl-2-pentene-1-al was administered by gavage to five male Wistar rats in five dose groups in a logarithmic series, weighing 90 to 120 g after fasting. Study duration was 14 days. The oral LD (males) was determined to be 4290 mg/kg bw, with 95 % fiducial limits of 3070 – 5980 mg/kg bw. LD50 values and their fiducial range are estimated by the method of Thompson (1947) using the tables of Weil (1952). No information is given on mortality patterns, signs of toxicity , or necropsy (Smyth, 1954).
Dermal:
The test article 2-methyl-2-pentene-1-al was administered to groups of four male New Zealand White rabbits weighing 2.5 to 3.5 kg. The test material was applied to the shaved intact skin of the animals, covering 1/10 of the entire trunk area. The test article was retained beneath an impervious plastic film. After 24 hours contact the film was removed, and mortality was considered complete after 14 additional days. The test item showed a median LD50 of 4.5 mL/kg , corresponding to 4000 mg/kg bw. The 95 % fiducial limits were 2.0 – 9.8 mL/kg, corresponding to 1960 – 8624 mg/kg bw (assuming a density of abt. 0.9 g/mL of the test material) (Smyth, 1954).
Inhalation:
In an acute inhalation toxicity study, one group of rats (6 males) were exposed by inhalation route to concentrations of 2-methyl-2-pentene-1-al in essentially logarithmic series with a factor of 2 for 4 hours at 20°C. Animals then were observed for 14 days. During the 14 days observation period, 3/6 animals died at a concentration of 2000 ppm (corresponding to 8100 mg/m³ air). No death occurred during 1 h concentrated vapour inhalation by rats. No detail on clinical/mortality signs is given (Smyth, 1954).
Justification for classification or non-classification
No classification and labelling for acute oral and dermal toxicity is necessary according to Directive 67/548/EEC(DSD) or Regulation (EC) No 1272/2008 (GHS (EU-CLP)) criteria. For inhalation toxicity, the substance was classified Xn, R20 - Harmful by inhalation according to Directive 67/548/EEC (DSD), and acute toxic, cat 3 (Inhalation, vapour) according to Regulation (EC) No 1272/2008 (GHS (EU-CLP)) criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.