Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 405-430-6 | CAS number: 65143-89-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP, guideline study
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Remarks:
- Not specified in report.
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.4470 (Acute Dermal Irritation)
- Qualifier:
- according to guideline
- Guideline:
- other: MAFF Primary Dermal Irritation Study, 1985. EEC Methods Number B.4 Dermal Irritation 19 Sept 1988.
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 405-430-6
- EC Name:
- -
- Cas Number:
- 65143-89-7
- Molecular formula:
- UVCB
- IUPAC Name:
- Reaction mass of Benzene sulfonic acid, hexadecyl(sulfophenoxy)-,disodium salt and Benzene sulfonic acid, - oxibis[hexadecyl]-, disodium salt
- Test material form:
- other: aqueous solution
- Details on test material:
- Test material: Dowfax 8390
Reference: lot# 68364M960202-1-2
10% aqueous material as diluted by the sponsor
Source: DPO/HTF/Surfactants, Larkin Lab, The Dow Chemical Company
Appearance: clear liquid
pH: ~9
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- The dermal irritation study was conducted on male and female New Zealand White rabbits which weighed from 2.030 to 2.359 kg, at study start, and were obtained from Covance Research Products, Inc., Denver, PA. Rabbits were born on April 12, 1997; dosed on July 22, 1997 and the study was terminated on July 28, 1997. Upon arrival to the laboratory, the animals were examined for health status by the laboratory veterinarian. All rabbits were acclimated to the laboratory environment for at least two weeks prior to study start. Animals were identified by a uniquely numbered metal eartag. Animals were housed individually in animal care facilities fully accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International. The animal rooms of the testing facility were designed to maintain adequate environmental conditions concerning temperature, humidity, photocycle and air exchanges. The relative humidity was maintained within a range of 40-60%, for rabbits. The building alarm system was set to
activate if relative humidity went below 39% or above 61%. The room temperature was maintained at 19±3°C, for rabbits. The building alarm system was set to activate if the temperature went below 16°C or above 22°C. A 12 hour light/dark photocycle was maintained for all animal rooms with lights on at 7:00 a.m. and off at 7:00 p.m. Room air was exchanged 15 times/hour, and the water lines automatically bled every six hours. Animals received approximately four ounces of Certified LabDiet #5322 (PMI Feeds, St. Louis, MO) per day. Tap water from the municipal water supply was supplied ad libitum. Water and feed analyses were performed as stated in the Standard Operating Procedures of The Toxicology Research Laboratory. No contaminants were found which would have affected the integrity of the study. Copies of the results of these analyses are maintained in the Toxicology Research Laboratory. Routine monitoring on weekends was limited to animal husbandry procedures required to ensure the availability of feed and water.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- The application sites were graded for erythema and edema within thirty minutes, 24, 48 and 72 hours, and when necessary, at 7 days after test
material removal. - Number of animals:
- 9/sex/application (3/sex were dosed with Dowfax 8390, STEOL CS-370 or VISTA C-550 SLURRY)
- Details on study design:
- The day prior to study start, an area approximately 10 cm x 10 cm of the back, of nine male and nine female New Zealand White rabbits, was clipped free of fur. On test day 1, a 0.5 ml aliquot of each respective test material was applied to an intact site on the backs of six rabbits per test material and covered with a gauze patch with cotton backing. The gauze patch was held in place with an elastic rabbit jacket. The jacket and patch were
removed after four hours and the back was wiped with a damp disposable towel to remove any residual test substance. The application sites were graded for erythema and edema within thirty minutes, 24, 48 and 72 hours, and when necessary, at 7 days after test material removal. Animals were weighed on the day of treatment and at study termination.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: within 30 minutes, 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: within 30 minutes, 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritant / corrosive response data:
- There were no signs of dermal irritation of the test site in any of the six rabbits that were dosed with DOWFAX 8390. The rabbits administered
DOWFAX 8390 were terminated after 72 hours. - Other effects:
- Dermal application of Dowfax 8390 did not have any effect on body weight.
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- other: not classifiable
- Remarks:
- Criteria used for interpretation of results: other: EU GHS
- Conclusions:
- There were no signs of dermal irritation of the test site in any of the six rabbits that were dosed with DOWFAX 8390.
- Executive summary:
DOWFAX* 8390, lot #68364M960202-1-2, was evaluated for primary dermal irritation. Aliquots of 0.5 ml of the test material (10% aqueous materials as diluted by the sponsor) were applied for four hours to the intact skin on the backs of groups of six New Zealand White rabbits per test material. There were no signs of dermal irritation of the test site in any of the six rabbits that were dosed with DOWFAX 8390. The rabbits administered DOWFAX 8390 were terminated after 72 hours. . There was no effect on the body weights of the rabbits.
*Trademark of The Dow Chemical Company
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.