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EC number: 224-698-3 | CAS number: 4454-05-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
- Reference Type:
- publication
- Title:
- The Acute Toxicity of Methoxydihydropyran.
- Author:
- Dodd DE et al.
- Year:
- 1 988
- Bibliographic source:
- Vet Hum Toxicol 30: 545-550
- Reference Type:
- secondary source
- Title:
- 3,4-Dihydro-2-methoxy-2H-pyran (CAS No. 4454-05-1)
- Author:
- OECD
- Year:
- 2 003
- Bibliographic source:
- cited in OECD SIDS 3,4-Dihydro-2-methoxy-2H-pyran for SIAM 16, 27-30 May 2003, Paris, France.
- Reference Type:
- publication
- Title:
- No information
- Year:
- 2 001
- Bibliographic source:
- cited in RTECS 01
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- Occlusive dressing
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3,4-dihydro-2-methoxy-2H-pyran
- EC Number:
- 224-698-3
- EC Name:
- 3,4-dihydro-2-methoxy-2H-pyran
- Cas Number:
- 4454-05-1
- Molecular formula:
- C6H10O2
- IUPAC Name:
- 2-methoxy-3,4-dihydro-2H-pyran
- Details on test material:
- - Name of test material (as cited in study report): Methoxydihydropyran
- Analytical purity: 99.105%
- Impurities (identity and concentrations): 0.643% of the Methoxydihydropyran dimer and 0.037% acrolein
- Lot/batch No.: not reported
- Stability under test conditions: not reported
- Storage condition of test material: not reported
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: males 2564-2574 g and females 2522-2566 g
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Type of wrap if used: Polyethylene sheeting and VETRAP Bandaging tape
REMOVAL OF TEST SUBSTANCE
- Washing: no, residual test substance was removed with cleansing tissue.
- Time after start of exposure: 24 hrs - Duration of exposure:
- 24 h
- Doses:
- 2, 4, 8 ml/kg bw (corresponding to 2000, 4000, 8000 mg/kg bw) Calculation based on density of the test substance (1 g/ml).
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: twice daily for signs of intoxication, body weight was measured before, at 7 and 14 days post exposure.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- LD50 values were calculated by the moving average method described by Thompson (Bact Rev 11:115, 1947) and Weil (Drug Chem Toxicol 6:595, 1983).
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 4 920 mg/kg bw
- 95% CL:
- 3 580 - 6 750
- Mortality:
- 0/1, 1/5 and 5/5 animals (both male and females) died in the 2000, 4000, 8000 mg/kg bw dose groups, respectively. Most deaths occurred within a day of application or the day following removal of the dressing, except one female in the 4000 mg/kg bw dose group who died 8 days after removal of the dressing.
- Clinical signs:
- other: Signs observed in all doses were comatose appearance at 15 to 25 min, sluggishness during the 24 hr contact period, and labored breathing and emaciated appearance at 7 and 14 d.
- Gross pathology:
- Necropsy of animals that died revealed dark red lungs and red patches in the trachea. Survivors showed mottled pink or red discoloration of the lungs.
- Other findings:
- Local findings: Erythema and oedema were seen in some animals after removal of the occlusive dressing, with erythema persisting in a few animals for 7 d. A few animals that died from 8000 mg/kg bw had ecchymoses. Desquamation was seen at 7 and 14 day after exposure.
Applicant's summary and conclusion
- Executive summary:
This study is comparable to the guideline and is reliable without restrictions. Undiluted test substance was applied to clipped skin of 10 rabbits (5 males and 5 females) under occlusive conditions for 24 h at concentrations of 2000, 4000 and 8000 mg/kg bw. 0/1, 1/5 and 5/5 animals (both male and females) died in the 2000, 4000 and 8000 mg/kg bw dose groups, respectively. The LD50 was found to be 4920 mg/kg bw for male and female animals. Signs observed in all doses were comatose appearance at 15 to 25 min, sluggishness during 24 hr contact period, and labored breathing and emaciated appearance at 7 and 14 d. Decrease in body weight gain was observed in the survivors. Necropsy of animals that died revealed dark red lungs and red patches in the trachea. Survivors showed mottled pink or red discoloration of the lungs.
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