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Diss Factsheets
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EC number: 204-846-3 | CAS number: 127-51-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from computational model developed by USEPA
- Justification for type of information:
- Data is from computational model developed by USEPA
- Qualifier:
- according to guideline
- Guideline:
- other: Modeling database
- Principles of method if other than guideline:
- ECOSAR estimates log Kow values using the US EPA's KOWWIN Program for aquatic toxicity.Toxicity of a chemical was measured on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program based upon the octanol /water partition coefficient (Kow). Data from ECOSAR class,neutral organics was used.
The estimation methods in EPI Suite™ have been developed by government, academic, and private sector researchers over many years and represent some of the best techniques currently available. The intended application domain of EPI Suite is organic chemicals, and inorganic as well as organometallic chemicals generally can be considered outside the domain. - GLP compliance:
- no
- Analytical monitoring:
- not specified
- Test organisms (species):
- other: Fish
- Test type:
- not specified
- Water media type:
- not specified
- Total exposure duration:
- 96 h
- Reference substance (positive control):
- not specified
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1.428 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: Neutral organics
- Conclusions:
- On the basis of EPI suite, ECOSAR version 1.1, the LC 50 value for short term toxicity to fish was predicted to be 1.428 mg/l for test material in 96hrs.
- Executive summary:
Based on the prediction done by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the LC 50 value for short term toxicity to fish was predicted.On the basis of this program, the LC 50 value for short term toxicity to fish was predicted to be 1.428 mg/l for test materialin 96 hrs.Based on this value it can be concluded that the substance is considered to be toxic to aquatic environment and can be classified as aquatic acute 2 as per the criteria mentioned in CLP regulation.
Reference
Description of key information
Short term toxicity to fish:
Based on the prediction done by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the LC 50 value for short term toxicity to fish was predicted.On the basis of this program, the LC 50 value for short term toxicity to fish was predicted to be 1.428mg/l for test materialin 96 hrs.Based on this value it can be concluded that the substance is considered to be toxic to aquatic environment and can be classified as aquatic acute 2 as per the criteria mentioned in CLP regulation.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1.428 mg/L
Additional information
Short term toxicity to fish:
The toxicity of test material was evaluated for fish using a predicted study and to support the prediction data , study from secondary source of structurally similar read across substance was also used.
Based on the prediction done by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the LC 50 value for short term toxicity to fish was predicted.On the basis of this program, the LC 50 value for short term toxicity to fish was predicted to be1.428mg/l for test materialin 96 hrs.Based on this value it can be concluded that the substance is considered to be toxic to aquatic environment and can be classified as aquatic acute 2 as per the criteria mentioned in CLP regulation.
The above prediction was further supported by data from secondary source, experimental study for test chemical was conducted according to guideline 203. Rainbow Trout (average length, 5.8 cm), were exposed to a series of 5 test concentrations of 0, 7.8, 10.9, 15.3, 21.4, or 30 mg/L dispersed in Polysorbate 80 (10 mg/L) for 96 hours at 17.1 °C. Control fish were exposed to polysorbate 80 (10 mg/L). Fish were observed twice daily for mortality and symptoms. pH values and water temperature were monitored after substance addition at 24 hour intervals. Dissolved oxygen was measured at the beginning of the experiment and at 96 hours. The LC50 value for the given test material is 10.9 mg/L.Based on the above effect concentration it can be concluded that test material is toxic to fish and can be classified as aquatic acute 2.
According to another study from secondary source , as per the guideline 203, Rainbow Trout (average length, 6-8 cm), were exposed to a series of 2 test concentrations of 0, 5, or 10 mg/L of4-(2,6,6-trimethylcyclohex-1-en-1-yl)but-3-en-2-onefor 96 hours at 16+/-1°C.During experiment the LC0 was determined to be 5 mg/L while LC100 as 10 mg/L. Thus LC50 value for the given test material was considered to be between 5mg/L and 10 mg/L.Based on the above effect concentration it can be concluded that test material is toxic to fish and can be classified as aquatic acute 2.
In a data from peer reviewed handbook it was observed that,short term toxicity of test material was evaluated for Leuciscus idus fish for 96 h . The minimum leathel effect concentration (LC50) was observed to be 6.8 mg/l.
Based on the above effect concentrations it can be concluded that test material is toxic to fish and can be classified as aquatic acute 2.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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