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EC number: 208-048-6 | CAS number: 506-64-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant, guideline study, available as an unpublished report.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Silver cyanide
- EC Number:
- 208-048-6
- EC Name:
- Silver cyanide
- Cas Number:
- 506-64-9
- Molecular formula:
- CAgN
- IUPAC Name:
- silver(1+) cyanide
- Test material form:
- not specified
- Details on test material:
- - Name of test material: silver cyanide
- Substance type: not reported
- Physical state: not reported
- Expiration date of the lot/batch: not supplied
- Stability under test conditions: not reported
- Storage condition of test material: Room temperature in the dark.
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Harlan Laboratories UK Ltd., Leicestershire, UK
- Age at study initiation: 12- 14 weeks old
- Weight at study initiation: 2.54 kg
- Housing: in a suspended cage
- Diet: 2930C Tekland Global Rabbit Diet (Harlan Laboratories UK Ltd., Oxon, UK) ad libitum
- Water: drinking water avaialble ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17 to 23
- Humidity (%): 30 to 70
- Air changes (per hr): at least 15 air changes per hour
- Photoperiod: 16 h darkness : 8 h light
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 100 mg - Duration of treatment / exposure:
- The test item was placed into the conjunctival sac of the right eye, formed by gently pulling the lower lid away from the eyeball. The upper and lower eyelids were held together for about one second immediately after treatment, to prevent loss of the test item, and then released.
- Observation period (in vivo):
- Assessment of ocular damage or irritation was made approximately 1 and 2 hours after treatment.
- Number of animals or in vitro replicates:
- The test item was applied to the right eye of one rabbit.
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: none
SCORING SYSTEM: Assessment of ocular damage/irritation was made according to the numerical evaluation (Draize 1977).
TOOL USED TO ASSESS SCORE: Standard ophthalmoscope.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- animal #1
- Time point:
- other: 1 hour
- Score:
- 21
- Max. score:
- 110
- Irritation parameter:
- overall irritation score
- Basis:
- animal #1
- Time point:
- other: 2 hours
- Score:
- 41
- Max. score:
- 110
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: 1 hour
- Score:
- 0
- Max. score:
- 80
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: 2 hours
- Score:
- 20
- Max. score:
- 80
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 1 hour
- Score:
- 5
- Max. score:
- 10
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 2 hours
- Score:
- 5
- Max. score:
- 10
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 1 hour
- Score:
- 16
- Max. score:
- 20
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 2 hours
- Score:
- 16
- Max. score:
- 20
- Irritant / corrosive response data:
- Iridial inflammation and severe conjunctival irritation were noted 1 hour after treatment. Diffuse corneal opacity, iridial inflammation, severe conjunctival irritation were noted 2 hours after treatment.
- Other effects:
- Blood stained discharge was noted and the animal appeared lethargic 2 hours after treatment.
Applicant's summary and conclusion
- Interpretation of results:
- highly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Silver cyanide was considered to be at least a severe irritant to the rabbit eye and would be classified in category 1 (serious eye damage/irreversible effects on the eye) according to GHS and EU CLP 1272/2008.
- Executive summary:
The study was performed to assess the irritancy potential of silver cyanide to the eye of the New Zealand White rabbit. The test was conducted according to OECD 405 and EC B.5 guidelines. A single application of silver cyanide to the non-irrigated eye of one rabbit produced diffuse corneal opacity, iridial inflammation, severe conjunctival irritation and blood stained discharge. The animal was also lethargic two hours after dosing. The test item, silver cyanide, was considered to be at least severely irritant to the rabbit eye (based on one rabbit only) and, therefore, would be classified in category 1 (serious eye damage/irreversible effects on the eye) according to GHS and EU CLP 1272/2008.
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