Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 700-253-3 | CAS number: 115258-10-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2009-09-02 to 2010-03-09
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Monitored GLP study, following international guidelines
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-D (Determination of the "Ready" Biodegradability - Manometric Respirometry Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- N-(3-{1,1,1,5,5,5-hexamethyl-3-[(trimethylsilyl)oxy]trisiloxan-3-yl}propyl)prop-2-enamide
- EC Number:
- 700-253-3
- Cas Number:
- 115258-10-1
- Molecular formula:
- C15H37NO4Si4
- IUPAC Name:
- N-(3-{1,1,1,5,5,5-hexamethyl-3-[(trimethylsilyl)oxy]trisiloxan-3-yl}propyl)prop-2-enamide
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): supplied by the sewage works of Rossdorf, Germany
- Storage conditions: after inital washing aeration overnight
- Storage length: overnight
- Preparation of inoculum for exposure:dilution to stock concentration in test water
- Pretreatment: 3x wash in tap water, centrifugation and resuspension, finally in test water
- Concentration of sludge: stock suspension: 1.5 g/L (on dry matter base)
- Initial cell/biomass concentration: final concentration in test vessel: 31 mg/L
- Test water: reconstituted by adding analytical grade salt solutions - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 25 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: see block "Any other informations on matgerial and methods, incl. tables"
- Additional substrate: no
- Solubilising agent (type and concentration if used): not applicable
- Test temperature: 22 +-1 °C
- pH: Start of test: 7.6; end of test: 6.6 - 7.5
- Aeration of dilution water: yes (before dilution)
- Suspended solids concentration: final concentration in test vessel: 31 mg/L
- Continuous darkness: yes
- Other:
TEST SYSTEM
- Number of culture flasks/concentration: 2
- Method used to create aerobic conditions: no data
- Method used to create anaerobic conditions: not applicable
- Measuring equipment: BSB Sensomat system, Aqualytic Dortmund
- Test performed in closed vessels due to significant volatility of test substance: no
- Test performed in open system: no
- Details of trap for CO2 and volatile organics if used: Potassium hydroxide solution (45%)
SAMPLING
- Sampling frequency: daily
- Sampling method: not applicable
- Sterility check if applicable: not applicable
- Sample storage before analysis: not applicable
CONTROL AND BLANK SYSTEM
- Inoculum blank: 2 x
- Abiotic sterile control: no
- Toxicity control:1 x (HgCl2)
Reference substance
- Reference substance:
- benzoic acid, sodium salt
Results and discussion
% Degradation
- Parameter:
- % degradation (O2 consumption)
- Value:
- 0
- Sampling time:
- 28 d
- Details on results:
- Over the whole test period 0% consumtion/degradation could be observed. Results calculated with THOD (NO3) and ThOD (NH4) were identical.
BOD5 / COD results
- Results with reference substance:
- Results with reference substance bencoic acid, sodium salt and the toxic control with HgCl2 were vaild.
Any other information on results incl. tables
I. Cumulative Biochemical Oxygen Demand (mg O2/L) in Test Flasks During the Test Period of 28 Days
Time |
Flask No. |
|||||||
(days) |
1 |
2 |
3 |
4 |
5 |
6 |
7 |
|
1 |
0 |
0 |
0 |
0 |
55 |
0 |
50 |
|
2 |
0 |
0 |
0 |
0 |
85 |
0 |
85 |
|
3 |
0 |
5 |
0 |
5 |
115 |
0 |
110 |
|
4 |
5 |
5 |
5 |
5 |
120 |
0 |
115 |
|
5 |
5 |
5 |
5 |
10 |
125 |
0 |
125 |
|
6 |
5 |
5 |
5 |
10 |
130 |
0 |
130 |
|
7 |
10 |
10 |
10 |
10 |
135 |
0 |
135 |
|
8 |
10 |
10 |
10 |
10 |
140 |
0 |
140 |
|
9 |
10 |
10 |
10 |
10 |
145 |
0 |
145 |
|
10 |
10 |
10 |
10 |
10 |
145 |
0 |
145 |
|
11 |
10 |
10 |
10 |
10 |
150 |
0 |
150 |
|
12 |
10 |
10 |
10 |
10 |
150 |
0 |
150 |
|
13 |
10 |
10 |
10 |
10 |
155 |
0 |
155 |
|
14 |
10 |
10 |
10 |
10 |
155 |
0 |
160 |
|
15 |
15 |
10 |
15 |
15 |
160 |
0 |
165 |
|
16 |
15 |
15 |
15 |
15 |
165 |
0 |
170 |
|
17 |
15 |
15 |
15 |
15 |
165 |
0 |
180 |
|
18 |
15 |
15 |
15 |
15 |
170 |
0 |
190 |
|
19 |
15 |
15 |
15 |
15 |
175 |
0 |
200 |
|
20 |
15 |
15 |
15 |
15 |
175 |
0 |
200 |
|
21 |
15 |
15 |
15 |
15 |
175 |
0 |
200 |
|
22 |
15 |
15 |
15 |
15 |
180 |
0 |
200 |
|
23 |
15 |
15 |
15 |
15 |
180 |
0 |
200 |
|
24 |
15 |
15 |
15 |
15 |
180 |
0 |
200 |
|
25 |
15 |
15 |
15 |
20 |
180 |
0 |
200 |
|
26 |
15 |
15 |
15 |
20 |
180 |
0 |
205 |
|
27 |
15 |
15 |
20 |
20 |
185 |
0 |
205 |
|
28 |
15 |
15 |
20 |
20 |
185 |
0 |
205 |
|
where
Flasks 1 and 2: 2-Propenamide, N-[3-[3,3,3-trimethyl-1,1-bis[(trimethylsilyl)oxy]-1-disiloxanyl]propyl]
Flasks 3 and 4: inoculum control
Flask 5: reference (procedure control)
Flask 6: abiotic control
Flask 7: toxicity control
II. pH Values of the test solutions after the test period (28 d)
Flask No. |
Treatment |
pH-value |
1 |
2-Propenamide, N-[3-[3,3,3-trimethyl-1,1-bis[(trimethylsilyl)oxy]-1-disiloxanyl]propyl] |
7.5 |
2 |
2-Propenamide, N-[3-[3,3,3-trimethyl-1,1-bis[(trimethylsilyl)oxy]-1-disiloxanyl]propyl] |
7.5 |
3 |
Inoculum control |
7.5 |
4 |
Inoculum control |
7.5 |
5 |
Procedure control |
7.5 |
6 |
Abiotic control |
6.6 |
7 |
Toxicity control |
7.5 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- The substance 2-Propenamide, N-[3-[3,3,3-trimethyl-1,1-bis[(trimethylsilyl)oxy]-1-disiloxanyl]propyl] is considered not to be readily biodegradable.
- Executive summary:
The test item 2-Propenamide, N-[3-[3,3,3-trimethyl-1,1-bis[(trimethylsilyl)oxy]-1-disiloxanyl]propyl] was investigated for its ready biodegradability in a manometric respirometry test over a period of 28 days. The biodegradation was followed by the oxygen uptake of the micro-organisms during exposure. As a reference item sodium benzoate was tested simultaneously under the same conditions as the test item, and functioned as a procedure control.
Degradation rate of test item calculated by the oxygen consumption of the aerobic activated sludge microorganisms after 28 days of incubation.
The test item 2-Propenamide, N-[3-[3,3,3-trimethyl-1,1-bis[(trimethylsilyl)oxy]-1-disiloxanyl]propyl] contains nitrogen, therefore the evaluation of biodegradation has to be based on ThODNH4andThODNO3. The criterion for ready biodegradability under the conditions of a manometric respirometry test is the 10-day window, describing the period between reaching at least 10% degradation and 60% degradation. This period should not exceed 10 days.
The mean biodegradation after 28 days of 2-Propenamide, N-[3-[3,3,3-trimethyl-1,1-bis[(trimethylsilyl)oxy]-1-disiloxanyl]propyl] was -2% (ThODNH4+ThODNO3); the 10 day window criterion was not passed.
Therefore, 2-Propenamide, N-[3-[3,3,3-trimethyl-1,1-bis[(trimethylsilyl)oxy]-1-disiloxanyl]propyl] is considered not to be readily biodegradable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.