Registration Dossier
Registration Dossier
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EC number: 205-793-9 | CAS number: 151-56-4
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: No GLP compliance and no data on guidelines compliance.
Data source
Reference
- Reference Type:
- publication
- Title:
- THE EFFECT OF CERTAIN ETHYLENEIMINES ON RENAL FUNCTION
- Author:
- JACKSON J, JAMES RMV
- Year:
- 1 963
- Bibliographic source:
- Brit. J. Pharmacol. (1963), 21, 581-589.
Materials and methods
- Principles of method if other than guideline:
- 5-10 animals, injected with graded doses of the compounds, deaths being observed up to 4 weeks.
- GLP compliance:
- no
Test material
- Reference substance name:
- Aziridine
- EC Number:
- 205-793-9
- EC Name:
- Aziridine
- Cas Number:
- 151-56-4
- Molecular formula:
- C2H5N
- IUPAC Name:
- aziridine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- No. of animals per sex per dose:
- 5-10 animals, injected with graded doses of the compounds, deaths being observed up to 4 weeks.
- Control animals:
- not specified
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- 3.5 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
LD50 are based on a period of 28 days.
Applicant's summary and conclusion
- Conclusions:
- LD50 = 3.5 mg/kg i.p.
- Executive summary:
Certain simple derivatives of ethyleneimine cause an intense and prolonged diuresis in nonhydrated rats. Sodium, potassium and chloride excretion is unaffected by these compounds. Ethyleneimine also causes a diuresis in the rat, but the polyfunctional compound thiotepa is ineffective. The relationship between structure and activity of a number of compounds is discussed with particular reference to the possibility that the diuresis is due to the in vivo liberation of ethyleneimine.
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