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Diss Factsheets
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EC number: 440-240-7 | CAS number: 1282554-35-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2009-08-07 to 2009-08-28
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: Guidelines for the Hazardous Evaluation of New Chemicals, HJ/T154-2004, China
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole
- IUPAC Name:
- 2-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Storage condition of test material: storage room of the institute, preservation condition normal temperature
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- not specified
Test organisms
- Test organisms (species):
- other: Gobiocypris rarus
- Details on test organisms:
- TEST ORGANISM- Code of test fish: GR-IHB-090414- Source: Institute of Hydrobiology, Chinese Academy of Sciences on April 14, 2009- Age at study initiation (mean and range, SD): not specified- Length at study initiation (length definition, mean, range and SD): 2 to 3 cm (total length)- Weight at study initiation (mean and range, SD): 0.2 to 0.3 g- Feeding during test: noneACCLIMATION- Acclimation period: 4 month- Acclimation conditions (same as test or not): same- Feeding frequency: daily until 24 hours the test is started- Health during acclimation (any mortality observed): None, no diseases were observed during acclimation period. No mortality observed during 7 days period prior to initiation of test
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 155 mg CaO3/L
- Test temperature:
- 23.3 - 24.7 °C
- pH:
- 6.75 - 7.84
- Dissolved oxygen:
- >90% of air saturation value (ASV)
- Salinity:
- not applicable
- Nominal and measured concentrations:
- nominal 60% and 80% saturated for measured concentrations refer to table 1
- Details on test conditions:
- TEST SYSTEM- Test vessel: 6L glass tanks- Aeration: yes- No. of organisms per vessel: 10- No. of vessels per concentration (replicates): 3- No. of vessels per control (replicates): 3- Biomass loading rate: ca 0.5 g Fish /LOTHER TEST CONDITIONS- Adjustment of pH: no- Photoperiod: 12 hours photoperiod daily, -feeding : none-oxigen concentration: >60% ASV-temperature: 23 +- 2°CEFFECT PARAMETERS MEASURED (with observation intervals if applicable) : mortality, abnormal response, pH, dissolved Oxygen and water temperature, concentration of test substance at the begining and end of test by HPLCTEST CONCENTRATIONS- Range finding study: yes- Test concentrations: three concentrations : saturated concentration (1.150 mg/L measured at start, 1.332 mg/L at the end of the test (96h)), 20% (0.414 mg/L measured at start, 0.481 mg/L at the end of the test (96h)), 4 % (under the LOQ of HPLC) of the saturated concentration and one blank all with no repetitions- Results used to determine the conditions for the definitive study: yes
- Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 0.897 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95% CL 0.88 to 0.99 mg/L
- Details on results:
- - Behavioural abnormalities: loss of equilibrium was observed in one fish at the test item treated group of saturated concentration - Mortality of control: yes
Any other information on results incl. tables
- Sublethal observations / clinical signs:
Test results over a period of 96 h
Test group
Replicates
0
24
48
72
96
*a
*b
*a
*b
*a
*b
*a
*b
*a
*b
Blank
1
0
none
0
none
1
none
1
none
1
none
2
0
none
0
none
1
none
1
none
1
none
3
0
none
0
none
0
none
0
none
1
none
Saturated solution
1
0
none
0
none
4
none
4
none
5
none
2
0
none
0
none
4
none
4
none
4
none
3
0
none
0
none
4
none
4
none
4
none
80% saturated solution
1
0
none
0
none
0
none
0
none
0
none
2
0
none
0
none
0
none
0
none
0
none
3
0
none
0
none
2
none
2
none
2
none
60 % saturated solution
1
0
none
0
none
0
none
0
none
0
none
2
0
none
0
none
0
none
0
none
0
none
3
0
none
0
none
0
none
0
none
0
none
*a= cumulative number of dead fishes
*b= abnormal responses
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 96-h LC50 value of > 0.897 mg/L +-10.69 µg/L (saturated concentration) to Gobiocypris rarus was determined for the test item under the conditions of the test.
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