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EC number: 613-701-7 | CAS number: 6485-45-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute Toxicity:
- oral: LD50: 1270 mg/kg bw (rat);
- inhalation: Inhalation Risk Test: mortality after 3 h exposure to saturated vapor;
- dermal: >= 1000 <= 2000 mg/kg bw (rat);
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 1 270 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 1 000 mg/kg bw
Additional information
Oral:
In a study which was in large parts equivalent to methods described in OECD guideline 401, the LD50 for oral acute toxicity in rats was calculated as 1270 mg/kg body weight (BASF AG, 1981; Val. 2). Doses of 681, 1000, 1470, 2150, 3160 mg/kg bw of a 75% cis / 25% trans-isomer mixture (CAS 6485-55-8) were applied by gavage followed by a post dose observation period of 14 days. In an earlier, similar study a LD50 for oral acute toxicity of 2,6-dimethylmorpholine (CAS 141-91-3) in rats was calculated as 2380 mg/kg body weight (BASF AG, 1975; Val. 2). In both studies the dyspnoea, apathy, staggering, atony, tremor, spastic gait, convulsions, ruffled fur, cyanosis, exsiccosis, salivation and poor general state. At necropsy, dilatation and congestive hyperemia of the heart and haemorrhagic stomachs were observed.
In a further study with only limited data provided, 2,6-dimethylmorpholine (CAS 141-91-3) caused likewise moderate toxicity after a single ingestion (LD50 = 2830 mg/kg bw; Smyth et al.1962; Val. 2).
Inhalation:
Data is available from an inhalation risk test (IRT) which meets generally accepted scientific principles (BASF AG, 1981; Val. 2). The inhalation of a saturated vapor-air mixture (75% cis / 25% trans-isomer mixture; CAS 6485-55-8) for 3 hours caused mortality. Clinical signs were escape attempts, eyelid closure, dyspnea, loss of pain reflex, tremor, irregular gait, ruffled fur.
In a second IRT the inhalation of a saturated vapor-air-mixture or 4000 ppm 2,6-dimethylmorpholine (CAS 141-91-3) for 4 h caused no mortality (Smyth et al. 1962; Val. 2).
Dermal:
2,6-dimethylmorpholine as a 75% cis / 25% trans-isomer mixture (CAS 6485-55-8) was applied by to the skin of groups of 3 rats/sex at doses of 1000 mg/kg and 2000 mg/kg bw in a occlusive dressing for 24 hours (BASF AG, 1981; Val. 2). Following treatment, rats were observed daily and a gross necropsy examination was performed at the time of scheduled euthanasia (day 14). All animals in the 2000 mg/kg bw dose died within 48 h and one female died in the 1000 mg/kg bw dose group. As a result an acute dermal LD50: >= 1000 <= 2000 mg/kg bw was determined. Main clinical signs observed were dyspnoea, apathy, staggering, tremor, spastic gait, ruffled fur, diarrhea, cyanosis, exsiccosis, eyelid closure and poor general state. Additionally severe cutaneous reactions (necrosis associated with edema) were noted. At necropsy, dilatation and congestive hyperemia of the heart, haemorrhagic stomachs and grey-colored lobular periphery of the liver were observed.
In a further study with only limited data provided, an acute dermal LD50 for 2,6-dimethylmorpholine (CAS 141-91-3) for rabbits of 662 mg/kg bw (710 ml/kg bw) was calculated (Smyth et al.1962; Val. 2).
Justification for classification or non-classification
EU classification according to Annex VI of Directive 67/548/EEC: Xn, R21/22
GHS classification: Acute Toxicity, oral: Cat. 4; acute toxicity, dermal: Cat. 4
The available studies on acute toxicity by inhalation are not fully suitable to assess this route of exposure, but the results suggest a LC 50 value greater than 20 mg/L (= no classification).
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