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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
toxicity to reproduction
Remarks:
other: not specified
Type of information:
other: publication
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Only short abstract available - Only secondary literature

Data source

Reference
Reference Type:
publication
Title:
Piperidine, 1-formyl-; N-Formylpiperidin; Formylpiperidine; N-Formylpiperidine; 1-Formylpiperidine; NFP; 1-Piperidinecarboxaldehyde; Piperidinoformamide
Author:
Canadian Centre for Occupational Health and Safety
Year:
2010
Bibliographic source:
Registry of Toxic Effects of Chemical Substances (RTECS®); http://ccinfoweb.ccohs.ca/rtecs/search.html; query date : July 2010

Materials and methods

Principles of method if other than guideline:
database data, no information is given on test method
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Piperidine-N-carbaldehyde
EC Number:
219-986-0
EC Name:
Piperidine-N-carbaldehyde
Cas Number:
2591-86-8
Molecular formula:
C6H11NO
IUPAC Name:
piperidine-1-carbaldehyde
Test material form:
not specified
Details on test material:
- Name of test material (as cited in study report) : Piperidine, 1-formyl-
- RTECS Number : TN0380000
- Synonyms/Trade Names : N-Formylpiperidin , Formylpiperidine , N-Formylpiperidine , 1-Formylpiperidine , NFP , 1-Piperidinecarboxaldehyde , Piperidinoformamide

Test animals

Species:
rat
Strain:
not specified
Sex:
female
Details on test animals or test system and environmental conditions:
No details available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on exposure:
No details available
Details on mating procedure:
No details available
Analytical verification of doses or concentrations:
not specified
Details on analytical verification of doses or concentrations:
No details available
Duration of treatment / exposure:
6 - 20 days after conception
Frequency of treatment:
no data
Details on study schedule:
no data
Doses / concentrations
Remarks:
Doses / Concentrations:
6600 mg/kg
Basis:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
No details available
Positive control:
No details available

Results and discussion

Results: P0 (first parental generation)

Effect levels (P0)

Dose descriptor:
other: TDLo
Effect level:
6 600 other: mg/kg
Based on:
not specified
Sex:
female
Basis for effect level:
other: Reference : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2 Volume (issue)/page/year: 18,96,1992
Remarks on result:
other: Generation not specified (migrated information)

Overall reproductive toxicity

Reproductive effects observed:
not specified

Any other information on results incl. tables

Toxic Effects :

Reproductive - Fertility - postimplantation mortality (e.g. dead and/or resorbed implants per total number of implants)

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

Applicant's summary and conclusion

Executive summary:

Piperidine, 1-formyl- was studied for its reproductive toxicity potential in rats. For Piperidine, 1-formyl- at a dose level of 6600 mg/kg bw the following toxic effects were reported :

Reproductive - Fertility - postimplantation mortality (e.g. dead and/or resorbed implants per total number of implants)

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)