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Diss Factsheets
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EC number: 903-816-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study protocol generally followed the O.E.C.D. Testing Guideline. However, only Salmonella tester strain TA!00 was used and the GLP regulations were not followed.
Data source
Reference
- Reference Type:
- publication
- Title:
- Mutagenic potential of allyl and allylic compounds. Structure-activity relationship as determined by alkylating and direct in vitro mutagenic properties
- Author:
- E. Eder, et. al.
- Year:
- 1 980
- Bibliographic source:
- Biochem Pharmacol. 1980 Apr 1;29(7):993- 8, 1980.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- yes
- Remarks:
- Only Salmonella tester strain TA100 was used.
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 3-chloropropene
- EC Number:
- 203-457-6
- EC Name:
- 3-chloropropene
- Cas Number:
- 107-05-1
- Molecular formula:
- C3H5Cl
- IUPAC Name:
- 3-chloroprop-1-ene
- Details on test material:
- As per the IUCLID5 Sections 1.1. - 1.4. for 3-chloropropene.
Constituent 1
Method
- Target gene:
- Histidine operon
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 100
- Metabolic activation:
- with and without
- Metabolic activation system:
- Induced Wistar rat liver S9 fraction with cofactors.
- Test concentrations with justification for top dose:
- Approximately 1532, 2870, 4783 and 5740 μg/plate.
- Vehicle / solvent:
- DMSO
Controls
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- not specified
- Positive controls:
- yes
- Positive control substance:
- other: epichlorohydrin
- Details on test system and experimental conditions:
- Salmonella strain TA100 was grown overnight at approximately 37 degrees C. The Preincubation method was used to control for volatility with an exposure period of 90 min with shaking in closed tubes with limited head space. The preincubation was conducted at 37 degrees C with and without rat liver S9 mix. Following preincubation treatment two mL of molten top agar was added to each tub and the contents mixed and poured over minimal glucose agar plates. The plates were inverted and incubated for 48 - 72 hr at 37 degrees C to allow revertant mutnat colonies to grow.
- Evaluation criteria:
- Generally a dose-responce relationship and two-fold increase in mean mutant frequency relative to the concurrent solvent background control value is considered to be a positive responce in tester strain TA100.
- Statistics:
- No data
Results and discussion
Test resultsopen allclose all
- Species / strain:
- S. typhimurium TA 100
- Metabolic activation:
- with
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Species / strain:
- S. typhimurium TA 100
- Metabolic activation:
- without
- Genotoxicity:
- positive
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Additional information on results:
- There was a dose-related increase in mutant frequency that reached > two-fold at the high dose level of 5740 ug/plate without rat liver metabolic activation.
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
positive without metabolic activation
3-Chloropropene induced a positive mutational responce in tester strain TA100 without rat liver metabolic activation S9 fraction. These data suggest that 3-chloropropene is a direct acting mutagen in this bacterial assay system. - Executive summary:
3 -Chloropropene, a structural analog of AC Light Ends was tested for mutagenic potential in an O.E.C.D. 471 "Bacterial Reverse Mutation Assay" by the preincubation method with and without rat liver derived S9 metabolic activation perperation. 3 -Chloropropene induced a positive mutational responce in tester strain TA100 without rat liver metabolic activation S9 fraction. These findings suggest that AC Light Ends would be mutagenic to Salmonella tester strain TA100 under similar experimental conditions.
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