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EC number: 423-740-1 | CAS number: 10461-98-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Test substance 2-cyclohexylidene-2-phenylacetonitrile was found to be toxic by oral route in acute category IV whether it is not harmful by dermal and inhalation exposure.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from test report
- Qualifier:
- according to guideline
- Guideline:
- other: 92/69/EEC, B1
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- other: (HanIbm:WIST (SPF))
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No data
- Route of administration:
- oral: unspecified
- Vehicle:
- corn oil
- Doses:
- 500,625,750 mg/kg bw
- No. of animals per sex per dose:
- 5 animals per dose/sex
- Control animals:
- not specified
- Details on study design:
- No details available
- Statistics:
- No details available
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 619 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 528.45 - 707.12
- Remarks on result:
- other: Slope of the mortality curve: 7.52
- Mortality:
- Male: 500 mg/kg bw; Number of animals: 5; Number of deaths: 1Male: 625 mg/kg bw; Number of animals: 5; Number of deaths: 2Male: 750 mg/kg bw; Number of animals: 5; Number of deaths: 327Female: 500 mg/kg bw; Number of animals: 5; Number of deaths: 0Female: 625 mg/kg bw; Number of animals: 5; Number of deaths: 4Female: 750 mg/kg bw; Number of animals: 5; Number of deaths: 5
- Clinical signs:
- other: Signs of toxicity related to dose levels:All deaths occurred on day 2 or 3 with the exception of 1 female who died on day 5.The following clinical signs were observed in animals from all dose groups between 1 hour and 8 days or until death occured:sedatio
- Gross pathology:
- Effects on organs:In the animals which were necropsied at termination of observation, no macroscopic organ findings were noted. In those who died spontaneously, stomach distended with gas was frequently observed. No other macroscopic abnormalities were noted.
- Other findings:
- No data
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- In acute oral toxicity by standard acute method test material 2-cyclohexylidene-2-phenylacetonitrile was applied at dose concentration 500,625,750 mg/kg bw on male and female HanIbm:WIST (SPF) rat resulted in LD50=619 mg/kg bw with 95% confidence level 528.45 — 707.12 and Slope of the mortality curve: 7.52.
- Executive summary:
In acute oral toxicity by standard acute method test material 2-cyclohexylidene-2-phenylacetonitrile was applied at dose concentration 500,625,750 mg/kg bw on 5 male and female HanIbm:WIST (SPF) rat in vehicle corn oil.
At all dose concentration rat showed the following effects:
Male: 500 mg/kg bw; Number of animals: 5; Number of deaths: 1
Male: 625 mg/kg bw; Number of animals: 5; Number of deaths: 2
Male: 750 mg/kg bw; Number of animals: 5; Number of deaths: 3
Female: 500 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 625 mg/kg bw; Number of animals: 5; Number of deaths: 4
Female: 750 mg/kg bw; Number of animals: 5; Number of deaths: 5
Clinical signs :
Signs of toxicity related to dose levels: All deaths occurred on day 2 or 3 with the exception of 1 female who died on day 5. The following clinical signs were observed in animals from all dose groups between 1 hour and 8 days or until death occured: sedation, dyspnea, ruffled fur, hunched posture, lying on stomach, emaciation. The body weight gain of the animals which survived the observation period was normal.
Gross pathology:
Effects on organs: In the animals which were necropsied at termination of observation, no macroscopic organ findings were noted. In those who died spontaneously, stomach distended with gas was frequently observed. No other macroscopic abnormalities were noted.
At the end of the experiment the LD50 value resulted in 619 mg/kg bw with 95% confidence level 528.45 — 707.12 and Slope of the mortality curve: 7.52.
Overall result indicate that the test substance 2-cyclohexylidene-2-phenylacetonitrile is categorized in acute oral toxicity IV as per the CLP criteria.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 619 mg/kg bw
- Quality of whole database:
- Data is K2 level from study report to which permission to refer granted by ECHA
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from test report
- Qualifier:
- according to guideline
- Guideline:
- other: 92/69/EEC
- GLP compliance:
- yes
- Test type:
- other: no data
- Limit test:
- yes
- Species:
- rat
- Strain:
- other: (HanIbm: WIST (SPF))
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No details available
- Type of coverage:
- occlusive
- Vehicle:
- other: none
- Details on dermal exposure:
- No data
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- No data
- Statistics:
- No data
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: confidence limit not available
- Mortality:
- Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
- Clinical signs:
- other: Signs of toxicity related to dose levels:There were no systemic signs of toxicity.
- Gross pathology:
- Effects on organs:There were no macroscopic abnormalities seen.
- Other findings:
- Signs of toxicity (local):There were no local signs of toxicity.
- Interpretation of results:
- not classified
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- In acute dermal toxicity test material 2-cyclohexylidene-2-phenylacetonitrile was applied at dose concentration 2000 mg/kg bw on male and female HanIbm:WIST (SPF) rat resulted in LD50=>2000 mg/kg bw .
- Executive summary:
In acute dermal toxicity test material 2-cyclohexylidene-2-phenylacetonitrile was applied dose concentration 2000 mg/kg bw for 24 hrs exposure period on 5 male and female HanIbm:WIST (SPF) rat with no vehicle.
At this dose concentration rat showed the following effects:
Mortality:
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
Signs of toxicity related to dose levels:There were no systemic signs of toxicity.
Gross pathology:
Effects on organs:
There were no macroscopic abnormalities seen.
Other findings:
Signs of toxicity (local):There were no local signs of toxicity.
At the end of the experiment the LD50 value resulted in >2000 mg/kg bw.
Overall result indicate that the test substance 2-cyclohexylidene-2-phenylacetonitrile is not classified as per the CLP criteria.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- Data is K2 level from study report to which permission to refer granted by ECHA
Additional information
Acute toxicity:Oral:
In acute oral toxicity by standard acute method test material 2-cyclohexylidene-2-phenylacetonitrile was applied at dose concentration 500,625,750 mg/kg bw on 5 male and female HanIbm:WIST (SPF) rat in vehicle corn oil.
At all dose concentration rat showed the following effects:
Male: 500 mg/kg bw; Number of animals: 5; Number of deaths: 1
Male: 625 mg/kg bw; Number of animals: 5; Number of deaths: 2
Male: 750 mg/kg bw; Number of animals: 5; Number of deaths: 3
Female: 500 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 625 mg/kg bw; Number of animals: 5; Number of deaths: 4
Female: 750 mg/kg bw; Number of animals: 5; Number of deaths: 5
Clinical signs :
Signs of toxicity related to dose levels: All deaths occurred on day 2 or 3 with the exception of 1 female who died on day 5. The following clinical signs were observed in animals from all dose groups between 1 hour and 8 days or until death occured: sedation, dyspnea, ruffled fur, hunched posture, lying on stomach, emaciation. The body weight gain of the animals which survived the observation period was normal.
Gross pathology:
Effects on organs: In the animals which were necropsied at termination of observation, no macroscopic organ findings were noted. In those who died spontaneously, stomach distended with gas was frequently observed. No other macroscopic abnormalities were noted.
At the end of the experiment the LD50 value resulted in 619 mg/kg bw with 95% confidence level 528.45 — 707.12 and Slope of the mortality curve: 7.52.
Overall result indicate that the test substance2-cyclohexylidene-2-phenylacetonitrile is categorized in acute oral toxicity IVas per the CLP criteria.
Acute toxicity: inhalation:
The chemical 2-cyclohexylidene-2-phenylacetonitrile has a low vapour pressure and thus exposure by the inhalation route is highly unlikely. Thus, the chemical is not likely to have acute toxicity effects via the inhalation route.
Acute toxicity:dermal :
In acute dermal toxicity test material 2-cyclohexylidene-2-phenylacetonitrile was applied dose concentration 2000 mg/kg bw for 24 hrs exposure period on 5 male and female HanIbm:WIST (SPF) rat with no vehicle.
At this dose concentration rat showed the following effects:
Mortality:
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
Signs of toxicity related to dose levels:There were no systemic signs of toxicity.
Gross pathology:
Effects on organs:
There were no macroscopic abnormalities seen.
Other findings:
Signs of toxicity (local):There were no local signs of toxicity.
At the end of the experiment the LD50 value resulted in >2000 mg/kg bw.
Overall result indicate that the test substance2-cyclohexylidene-2-phenylacetonitrile is not classified as per the CLP criteria.
Justification for selection of acute toxicity – oral endpoint
In acute oral toxicity by standard acute method test material 2-cyclohexylidene-2-phenylacetonitrile was applied at dose concentration 500,625,750 mg/kg bw on male and female HanIbm:WIST (SPF) rat resulted in LD50=619 mg/kg bw with 95% confidence level 528.45 — 707.12 and Slope of the mortality curve: 7.52.
Justification for selection of acute toxicity – inhalation endpoint
The chemical 2-cyclohexylidene-2-phenylacetonitrile has a low vapour pressure and thus exposure by the inhalation route is highly unlikely. Thus, the chemical is not likely to have acute toxicity effects via the inhalation route.
Justification for selection of acute toxicity – dermal endpoint
In acute dermal toxicity test material 2-cyclohexylidene-2-phenylacetonitrile was applied at dose concentration 2000 mg/kg bw on male and female HanIbm:WIST (SPF) rat resulted in LD50=>2000 mg/kg bw .
Justification for classification or non-classification
On the basis of information available, the substance 2-cyclohexylidene-2-phenylacetonitrile toxic by oral route in acute category IV and not expected to be toxic by inhalation and dermal exposure.
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