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EC number: 701-242-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Testing was conducted between 17 December 2009 and 08 April 2010.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results. The study report was conclusive, done to a valid guideline and the study was conducted under GLP conditions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- other: Not applicable
Test material
- Reference substance name:
- Reaction Products of C4 alcohols and C4 alkenes obtained as by-products from the manufacturing of butan-2-ol by sulfuric acid esterification and hydrolysis of butene
- EC Number:
- 701-242-6
- Molecular formula:
- A complex and variable combination of C4 hydrocarbons, 2,2'-oxybisbutane and butan-2-ol.
- IUPAC Name:
- Reaction Products of C4 alcohols and C4 alkenes obtained as by-products from the manufacturing of butan-2-ol by sulfuric acid esterification and hydrolysis of butene
Constituent 1
- Radiolabelling:
- no
Study design
- Test temperature:
- HPLC column maintained at 35°C by thermostatically controlled column heater. Note overall result is independent of test temperature as all values relative to literature values of calibration standards only.
HPLC method
- Details on study design: HPLC method:
- Please see any other information on materials and method section.
Due to the nature and tabular content of this information it would be rendered less comprehensible by splitting this information between sections.
Results and discussion
Adsorption coefficientopen allclose all
- Type:
- Koc
- Value:
- 17.8 - 925
- Remarks on result:
- other: Lower value is a limit value, i.e. <17.8
- Type:
- log Koc
- Value:
- 1.25 - 2.97
- Remarks on result:
- other: Lower value is a limit value, i.e. <1.25
Results: HPLC method
- Details on results (HPLC method):
- Please see any other information on Results and method section.
Due to the nature and tabular content of this information it would be rendered less comprehensible by splitting this information between sections.
Results: Batch equilibrium or other method
- Transformation products:
- not measured
Any other information on results incl. tables
Calibration
The retention times of formamide and the retention times, capacity factors (k) and log10 Kocvalues for the reference standards are shown in the two following tables:
Dead Time |
Retention Time (mins) |
Mean Retention Time (mins) |
|
Injection 1 |
Injection 2 |
||
Formamide |
2.158 |
2.162 |
2.160 |
Standard |
Retention Time (mins) |
Mean Retention Time (mins) |
Capacity Factor (k) |
Log10k |
Log10Koc |
|
Injection 1 |
Injection 2 |
|||||
Acetanilide |
2.704 |
2.704 |
2.704 |
0.252 |
-0.599 |
1.25 |
Phenol |
2.754 |
2.756 |
2.755 |
0.275 |
-0.560 |
1.32 |
Atrazine |
3.084 |
3.090 |
3.087 |
0.429 |
-0.367 |
1.81 |
Isoproturon |
3.321 |
3.327 |
3.324 |
0.539 |
-0.269 |
1.86 |
Triadimenol |
3.925 |
3.932 |
3.929 |
0.819 |
-8.69 x 10-2 |
2.40 |
Linuron |
4.549 |
4.555 |
4.552 |
1.107 |
4.43 x 10-2 |
2.59 |
Naphthalene |
4.283 |
4.286 |
4.285 |
0.984 |
-7.20 x 10-3 |
2.75 |
Endosulfan-diol |
5.495 |
5.498 |
5.497 |
1.545 |
0.189 |
3.02 |
Fenthion |
6.669 |
6.665 |
6.667 |
2.087 |
0.319 |
3.31 |
a-Endosulfan |
7.760 |
7.766 |
7.763 |
2.594 |
0.414 |
4.09 |
Phenanthrene |
6.811 |
6.821 |
6.816 |
2.156 |
0.334 |
4.09 |
Diclofop-methyl |
7.842 |
7.835 |
7.839 |
2.629 |
0.420 |
4.20 |
DDT |
15.218 |
15.237 |
15.228 |
6.050 |
0.782 |
5.63 |
Adsorption coefficient of sample
The retention times, capacity factors and log10Koc values determined for the sample are shown in the following table:
Peak |
Injection |
Retention Time |
Capacity |
Log10k |
Log10Koc |
Mean |
1 |
1 |
2.399 |
0.111 |
-0.956 |
<1.25 |
<1.25 |
2 |
2.394 |
0.108 |
-0.965 |
<1.25 |
||
2 |
1 |
2.977 |
0.378 |
-0.422 |
1.45 |
1.45 |
2 |
2.971 |
0.375 |
-0.425 |
1.44 |
||
3 |
1 |
3.226 |
0.494 |
-0.307 |
1.82 |
1.82 |
2 |
3.221 |
0.491 |
-0.309 |
1.82 |
||
4 |
1 |
4.603 |
1.131 |
5.35 x 10-2 |
2.97 |
2.97 |
2 |
4.597 |
1.128 |
5.24 x 10-2 |
2.96 |
Adsorption coefficient: <17.8 to 925
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The adsorption coefficient (Koc) of the test material has been determined to be in the range less than 17.8 to 925, log10 Koc <1.25 to 2.97. From the chromatographic profile, log10 Koc values of <1.25 and 1.82 were attributed to the butan-2-ol and 2,2’-oxybisbutane components of the test material respectively.
- Executive summary:
- The adsorption coefficient (Koc) of the test material has been determined to be in the range less than 17.8 to 925, log10Koc <1.25 to 2.97, using the HPLC screening method, Method C19 Adsorption Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008. From the chromatographic profile,log10Kocvalues of<1.25and 1.82 were attributed to the butan-2-ol and 2,2’-oxybisbutane components of the test material respectively.
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