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EC number: 277-749-7 | CAS number: 74181-84-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The in vitro skin irritation test showed inconclusive results with regard to skin irritation; however the in vitro skin corrosion test with the structurally related substance EDTA-Cu(NH4)2 was negative. In addition, two studies were available with EDTA-CuNa2 (see also read across document in section 13) on skin irritation, one using a 80% solution, the other study using a 50% solution. The 80% solution showed slight skin irritation but not sufficient for classification, the 50% solution did not show skin irritation.
The in vitro eye irritation test showed borderline irritation in the BCOP (score was 3.1 which is just > 3). No eye irritation was seen in vitro with EDTA-Cu(NH4)2.
Two in vivo studies were also available with EDTA-CuNa2 for eye irritation. The key study with EDTA-CuNa2 showed irritation just sufficient to require classification, the supporting study showed slight irritation not sufficient for classification.
Key value for chemical safety assessment
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Most metal chelates are not irritating to the eyes (see read across document in section 13). However, EDTA-CuK2, like EDTA-CuNa2 showed borderline eye irritation, just requiring classification and labeling. Most metal chelates are neither irritating to the skin; however, EDTA-CuK2 showed inconclusive results in vitro. Based on read across with EDTA-Cu(NH4)2 which was irritating but not corrosive to the skin in vitro, it was concluded that also EDTA-CuK2 was irritating to the skin.
Justification for classification or non-classification
Based on the results of the in vitro skin irritation study and read across with EDTA-CuNa2 and EDTA-Cu(NH4)2, it was concluded that no classification was needed for corrosion but for irritation. For the endpoint skin irritation classification with GHS Cat. 2 should be applied based on the skin irritation observed. Based on the in vitro eye irritation test and the in vivo results with EDTA-CuNa2, classification GHS Cat. 2 is required for eye irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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