Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 237-525-1 | CAS number: 13826-35-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Data is from online Chemical Repository Database
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Primary eye irritation study was performed on New Zealand White rabbits for 7 days.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-phenoxybenzylic alcohol
- EC Number:
- 237-525-1
- EC Name:
- 3-phenoxybenzylic alcohol
- Cas Number:
- 13826-35-2
- Molecular formula:
- C13H12O2
- IUPAC Name:
- (3-phenoxyphenyl)methanol
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): 3-Phenoxybenzyl alcohol
- Molecular formula (if other than submission substance): C13H12O2
- Molecular weight (if other than submission substance): 200.23318 g/mol
- Smiles notation (if other than submission substance): C1=CC=C(C=C1) OC2=CC=CC (=C2) CO
- InChl (if other than submission substance): InChI=1S/C13H12O2/c14-10-11-5-4-8-13(9-11)15-12-6-2-1-3-7-12/h1-9, 14H, 10H2
- Substance type: Organic
- Physical state: liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: The Ethyl Corporation, Ferndale, Michiga
- Age at study initiation: No data available
- Weight at study initiation: 2045 to 2330 grams
- Fasting period before study: No data available
- Housing: In hanging wire-mesh cages
- Diet (e.g. ad libitum): Purina Rabbit Chow(ad libitum)
- Water (e.g. ad libitum): Water(ad libitum)
- Acclimation period:
Or Test Tissue
- Source: not applicable
- Type: not applicable
- Acclimation : not applicable
- Housing conditions: not applicable
ENVIRONMENTAL CONDITIONS
- Temperature (°C): in temperature controlled quarters
- Humidity (%):in humidity controlled quarters
- Air changes (per hr):No data available
- Photoperiod (hrs dark / hrs light): No data available
IN-LIFE DATES: From: To: No data available
Test system
- Vehicle:
- not specified
- Controls:
- other: The left eye served as the untreated control for each rabbit.
- Amount / concentration applied:
- 0.1 milliliter of the undiluted test material
- Duration of treatment / exposure:
- The 3 rabbits in Group I did not receive a washout. The 3 rabbits in Group II received a 300 ml distilled water washout 5 minutes following instillation. This washout was accomplished over a one minute period.
- Observation period (in vivo):
- 24 hours following instillation,48 hours,72 hours,7 days
- Number of animals or in vitro replicates:
- 6 animals(3 male and 3 female)
- Details on study design:
- TEST SITE
- Area of exposure: not applicable
- % coverage: not applicable
- Type of wrap if used: not applicable
REMOVAL OF TEST SUBSTANCE
- Washing (if done): The 3 rabbits in Group II received a 300 ml distilled water washout 5 minutes following instillation. This washout was accomplished over a one minute period.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 7 days
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- not specified
- Remarks on result:
- other: Corneal luster was observed in unwashed eye.
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 7 days
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not specified
- Remarks on result:
- other: Iris irritation was observed in unwashed eye.
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 7 days
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not specified
- Remarks on result:
- other: Chemosis was observed in unwashed eye.
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 7 days
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- not specified
- Remarks on result:
- other: corneal luster was observed in washed eyes
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 7 days
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not specified
- Remarks on result:
- other: Iridal irritation was observed in washed eyes
Any other information on results incl. tables
For Group 1:Unwashed eye
Eye Irritation in the Albino rabbit
|
Average score (range) |
|||
|
Period |
|||
Area |
24 hours |
48 hours |
72 hours |
Days 7 |
Cornea |
0.5 |
0.5 |
0.5 |
0 |
Iris |
0 |
0 |
0 |
0 |
Conjunctivae |
0.6 |
0 |
0.6 |
0 |
Total score |
1.1 |
0.5 |
1.1 |
0 |
For Group 2: Washed eye
Eye Irritation in the Albino rabbit
|
Average score (range) |
|||
|
Period |
|||
Area |
24 hours |
48 hours |
72 hours |
Days 7 |
Cornea |
2.5 |
3.5 |
2.5 |
0 |
Iris |
0 |
0 |
0 |
0 |
Conjunctivae |
1.4 |
0.6 |
0.6 |
0 |
Total score |
3.9 |
4.1 |
3.1 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The end point for 3-Phenoxybenzylalcohol (CAS No :13826-35-2) on New Zealand white rabbits was found to be for
Group I (Unwashed Eyes): A possible primary eye irritant.
Group II (washed Eyes): A probable primary eye irritant. - Executive summary:
Eye irritation experiment was performed onNew Zealand white rabbits. 3 males and 3 female of weight 2045 and 2330 grams were used in this study. The rabbits were individually housed in hanging wire-mesh cages in temperature and humidity controlled quarters maintained in accordance with the recommendations contained in H.E.W. Publication No. 74-23 (N.I.H.) entitled "Guide for the Care and Use of Laboratory Animals".
The eyes of each rabbit were examined with ultraviolet light after instillation of one drop of 2.0 percent sodium fluorescein solution. The 6 rabbits were divided into 2 groups of 3 rabbits each and received 0.1 ml of undiluted test material.
The test material was placed on right eye and left eye was used as a control.Group I group did not receive washout and group II 3 rabbits received a 300 ml distilled water washout 5 minutes following instillation and observed on 24, 48, 72 hours and 7 days.
So, according to the grading system result found that concluded thatend point for 3-Phenoxybenzylalcohol (CAS No: 13826-35-2) on New Zealand white rabbits was found to be for Group I (Unwashed Eyes): A possible primary eye irritant.
Group II (washed Eyes): A probable primary eye irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
