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EC number: 208-523-8 | CAS number: 532-02-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Final Report on the Amended Safety Assessment of Sodium Polynaphthalenesulfonate and Sodium Naphthalenesulfonate1
- Author:
- Cytotest Cell Research GmbH & Co
- Year:
- 2 003
- Bibliographic source:
- International Journal of Toxicology, 22(Suppl. 2):37–44, 2003
Materials and methods
- Objective of study:
- absorption
- Principles of method if other than guideline:
- In Vitro Absorption study of 2-naphthalenesulfonic acid on pig skin
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium naphthalene-2-sulphonate
- EC Number:
- 208-523-8
- EC Name:
- Sodium naphthalene-2-sulphonate
- Cas Number:
- 532-02-5
- Molecular formula:
- C10H8O3S.Na
- IUPAC Name:
- sodium naphthalene-2-sulphonate
- Reference substance name:
- 2-naphthalenesulfonic acid
- IUPAC Name:
- 2-naphthalenesulfonic acid
- Details on test material:
- - Name of test material (as cited in study report): 2-naphthalenesulfonic acid (SNS)
- Molecular formula (if other than submission substance): C10-H8-O3-S.Na
C10-H7-O3-S.Na
- Molecular weight (if other than submission substance): 230.2183 g/mole
- Substance type: Organic
- Physical state: No data available
- Impurities (identity and concentrations): Not more than 0.5% sulfate (as sodium sulfate); not more than 20 mg/kg of heavy metals; and not more than 2 mg/kg arsenic.
Constituent 1
Constituent 2
- Radiolabelling:
- no
Test animals
- Species:
- pig
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: Diffusion of porcine skin
- Vehicle:
- other: Physiologic saline (0.9% NaCl solution)
- Details on exposure:
- The skin was mounted in each of four glass diffusion chambers with a total surface area exposed of 1.13 cm2. Receptor chambers were filled with 7ml of physiologic saline (0.9% NaCl solution) and 339 μl of SNS (at a concentration of 1 μg/μl in deionized water) was placed in donor chambers. Each donor chamber was covered with parafilm and the diffusion chambers placed in an incubator at 37◦C. Samples (0.5 ml) were drawn from the receptor chamber at regular intervals. After the sample was taken, 0.5 ml of deionized water was added to each receptor chamber to keep volume constant.
- Duration and frequency of treatment / exposure:
- Single
Doses / concentrations
- Remarks:
- Doses / Concentrations:
339 μl
- No. of animals per sex per dose / concentration:
- 1
- Control animals:
- yes, concurrent vehicle
- Positive control reference chemical:
- Data not available
- Details on study design:
- Samples were analyzed by measuring the amount of UV absorbed at 227 nm. The experiment was replicated once.
- Details on dosing and sampling:
- Data not available
- Statistics:
- Data not available
Results and discussion
- Preliminary studies:
- Data not available
Main ADME results
- Type:
- absorption
- Results:
- Small amounts were absorted from pig skin
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Small amounts of SNS were lost from the donor fluid by penetration through or absorption into porcine skin. Of the 339 μg applied, only around 5 μg was noncovalently bound to the skin and only approximately 1% of the applied material appeared in the receptor fluid.
- Details on distribution in tissues:
- Data not available
- Details on excretion:
- Data not available
Metabolite characterisation studies
- Metabolites identified:
- not specified
- Details on metabolites:
- Data not available
Bioaccessibility (or Bioavailability)
- Bioaccessibility (or Bioavailability) testing results:
- Data not available
Any other information on results incl. tables
Concentration (μg/ml) of Sodium Naphthalenesulfonate appearing in receptor chambers as a function of time (Cytotest Cell Research GmbH & Co. 1997)
|
Experiment 1 |
Experiment 2 |
||||||
Time (hours) |
Chamber 1 |
Chamber 2 |
Chamber 3 |
Chamber 4 |
Chamber 1 |
Chamber 2 |
Chamber 3 |
Chamber 4 |
0 |
0.00 |
0.08 |
0.05 |
0.01 |
0.09 |
0.13 |
0.10 |
0.10 |
0.5 |
0.13 |
0.14 |
0.14 |
0.08 |
0.14 |
0.09 |
0.09 |
0.14 |
1.0 |
0.14 |
0.17 |
0.16 |
0.09 |
0.17 |
0.13 |
0.14 |
0.19 |
2.0 |
0.24 |
0.25 |
0.28 |
0.22 |
0.22 |
0.17 |
0.25 |
0.25 |
4.0 |
0.24 |
0.28 |
0.28 |
0.18 |
0.31 |
0.27 |
0.39 |
0.33 |
6.0 |
0.34 |
0.42 |
0.37 |
0.29 |
0.38 |
0.34 |
0.50 |
0.36 |
8.0 |
0.31 |
0.49 |
0.41 |
0.33 |
0.38 |
0.32 |
0.55 |
0.35 |
24.0 |
0.51 |
0.53 |
0.52 |
0.62 |
0.49 |
0.44 |
0.75 |
0.58 |
Sodium Naphthalenesulfonate concentration in donor fluid (μg/ml) and the amount (μg) eluted from skin patches at the end of the experiment (Cytotest Cell Research GmbH & Co. 1997)
|
Experiment 1 |
Experiment 2 |
||
Chamber |
Concentration in donor fluid∗ |
Amount eluted from skin |
Concentration in donor fluid∗ |
Amount eluted from skin |
1 |
947.13 |
4.74 |
996.51 |
5.99 |
2 |
985.04 |
5.59 |
1003.49 |
5.69 |
3 |
995.51 |
5.19 |
1000.00 |
4.99 |
4 |
929.18 |
5.39 |
992.02 |
4.89 |
∗Sodium Naphthalenesulfonate was applied at a concentration of 1 μg/μl in a 339-μl aliquot.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): low bioaccumulation potential based on study results
On the basis of observed result it is concluded the 2-naphthalenesulfonic acid have very low absorption and expected to have Low bio-accumulation potential based on study results. - Executive summary:
In a in vitroAbsorption study, porcine skin of pig weremounted in diffusion chambers with a total surface area exposed of 1.13 cm2. Receptor chambers were filled with 7ml of physiologic saline (0.9% NaCl solution) and 339 μl of SNS (at a concentration of 1 μg/μl in deionized water) was placed in donor chambers. After 24 h, Skin patches were removed and eluted with 2 ml of deionized water, centrifuged
and the concentration of SNS in the supernatantwas determined. small amounts of SNS were lost from the donor fluid by penetration through or absorption into porcine skin. Of the 339 μg applied, only around 5 μg was noncovalently bound to the skin and only approximately 1% of the applied material appeared in the receptor fluid.Therefore, on the basis of observed result it is concluded the2-naphthalenesulfonic acidhavevery low absorptionandexpected to have Low bio-accumulation potential based on study results.
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