Registration Dossier
Registration Dossier
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EC number: 203-837-1 | CAS number: 111-13-7
Endpoint summary
Administrative data
Description of key information
Adsorption / desorption:
The adsorption coefficient Koc in soil and in sewage sludge of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 121 for testing of Chemicals (Experimental study report, 2017). A test item solution was prepared by accurately measuring 4μL of test item and diluted with methanol up to 10 ml. Thus, the test solution concentration was 327.6 mg/l. The pH of test substance was 6.95. The reference substances were chosen according to structural similarity with the test substance and calibration graph prepared. The reference substances were 2-nitrophenol, nitrobenzene, 4 -nitrobenzamide, N,N-dimethylbenzamide, N-methylbenzamide and benzamide having Koc value ranging from 1.239 to 2.47. The Log Koc value of test chemical was determined to be 1.8135 ± 0.001 at 25°C.This logKoc value indicates that the test chemical has a low sorption to soil and sediment and therefore have moderate migration potential to ground water.
Additional information
Adsorption / desorption:
Various experimental studies of the test chemical were reviewed for the adsorption end point which are summarized as below:
In an experimental key study from study report (2017),the adsorption coefficient Koc in soil and in sewage sludge of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 121 for testing of Chemicals. A test item solution was prepared by accurately measuring 4μL of test item and diluted with methanol up to 10 ml. Thus, the test solution concentration was 327.6 mg/l. The pH of test substance was 6.95. The reference substances were chosen according to structural similarity with the test substance and calibration graph prepared. The reference substances were 2-nitrophenol, nitrobenzene, 4 -nitrobenzamide, N,N-dimethylbenzamide, N-methylbenzamide and benzamide having Koc value ranging from 1.239 to 2.47. The Log Koc value of test chemical was determined to be 1.8135 ± 0.001 at 25°C.This logKoc value indicates that the test chemical has a low sorption to soil and sediment and therefore have moderate migration potential to ground water.
In a supporting study, adsorption experiment was conducted for estimating the adsorption coefficient (Koc) value of test chemical (authoritative database, 2017). The adsorption coefficient (Koc) value was calculated using a logKow of 2.37 and a regression derived equation. The adsorption coefficient (Koc) value of test chemical was estimated to be 460 (Log Koc = 2.66). This Koc value indicates that the test chemical has a moderate sorption to soil and sediment and therefore have slow migration potential to ground water.
On the basis of above overall results for test chemical (from study report and authoritative databases), it can be concluded that the logKoc value of test chemical ranges from 1.81–2.66indicating that the test chemical has a low to moderatesorption to soil and sediment and therefore have moderate to slow migration potential to ground water.
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