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Diss Factsheets
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EC number: 617-589-0 | CAS number: 84592-32-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Version / remarks:
- Cited as Directive 84/449/EEC, C.1 ("Acute toxicity for fish")
- GLP compliance:
- yes
Test material
- Reference substance name:
- [(5-(4-hydroxy-2,6,6-trimethyl-3-oxo-1-cyclohexen-1-yl)-3-methyl-2,4-pentadienyl](triphenyl)phosphonium bromide
- EC Number:
- 617-589-0
- Cas Number:
- 84592-32-5
- Molecular formula:
- C33 H36 O2 P .Br
- IUPAC Name:
- [(5-(4-hydroxy-2,6,6-trimethyl-3-oxo-1-cyclohexen-1-yl)-3-methyl-2,4-pentadienyl](triphenyl)phosphonium bromide
- Details on test material:
- - Name of test material (as cited in study report): Asta-C15-Salz krist.
- Lot/batch No.: 95149-4B/Trommel 2
- Analytical purity: 98 g/100 g
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: The test concentrations were prepared separately by adding the required amount of test substance to test medium. The mixture was stirred using an ultra-turrax stirrer.
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: Zebra fish
- Source: Charles River Aquatics, Someren, Netherlands
- Age at study initiation (mean and range, SD): ca. 3 month
- Length at study initiation (length definition, mean, range and SD): 3.3 cm (range: 2.9 - 3.6 cm)
- Weight at study initiation (mean and range, SD): 0.35 g (0.2 - 0.5 g)
ACCLIMATION
- Acclimation period: 3 days
- Type and amount of food: TETRA MIN, Tetra Werke, Melle, Germany; ad libitum
- Feeding frequency: daily and on workdays generally additionally live artemia
- Health during acclimation (any mortality observed): no mortality observed
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Test temperature:
- 23 - 24 °C
- pH:
- 8.0 - 8.5
- Dissolved oxygen:
- 5.7 - 8.1 mg/l
- Nominal and measured concentrations:
- Nominal test substance concentrations:
0, 4.64, 10.0, 21.5, 46.4 and 100 mg/l
Analytically determined test concentrations after 24 hours:
<2, 1.9, 4.9, 10.9, 26.8, 58.2 mg/l
Analytically determined test concentrations after 96 hours:
3.0 (4.64 nominal), 6.4 (10.0 nominal), 14.2 (21.5 nominal) mg/l - Details on test conditions:
- TEST SYSTEM
- Test vessel: glass aquaria (30 x 22 x 24 cm)
- Fill volume: 10 l
- Renewal rate of test solution (frequency/flow rate): renewal of test solution after 48 hours
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- Biomass loading rate: 0.4 g/l
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: tap water of the city of Frankenthal/Germany
OTHER TEST CONDITIONS
- Photoperiod: 16:8 h day-night regime
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
Mortality and symptoms of intoxication after 1, 4, 24, 48,72 and 96 hours
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 2.2
- Results used to determine the conditions for the definitive study: LC50 (96 h): 10 - 100 mg/l
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 4.64 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 14.67 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: geom. mean of 21.5 -46.4 mg/l
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- 46.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- At a test substance concentration of 21.5 mg/l apathy and swimnming near the bottom was obersved after 1 hour of exposure. At a concentration of 46.4 mg/l accelerated respiration, apathy, O :swimming near water surface and swimnming near the bottom were observed after 1 hours. At a test concentration of 100 mg/l a apathy and swimming near water surface was observed after 1 hour.
- Reported statistics and error estimates:
- Finney, D.J., Probit Analysis, Cambr. Univ. Press, 3rd ed., 1971
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.