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Diss Factsheets
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EC number: 432-820-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_environmental-fate-and-pathways.png)
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04 March 2002 to 07 March 2002.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, that do not affect the quality of relevant results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- In accordance with UK Principles of GLP (UK GLP Regulations 1999) which are in accordance with OECD Principles of GLP., revised 1997 (ENV/MC./CHEM(98)17).
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
Test material
- Details on test material:
- - Name of test material (as cited in study report): S178207
- Physical state: White solid
- Analytical purity: 91.4% total ligand
- Lot/batch No.: NBZ 0155/44
- Stability under test conditions: Stable
- Storage condition of test material: In the dark at ambient temperature.
Constituent 1
- Radiolabelling:
- no
Study design
- Test temperature:
- 20.3 - 22.9°C
HPLC method
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus: Analytical column packed with a silica matrix
- Type, material and dimension of analytical (guard) column: 25 cm x 4.6 mm i.d. column packed with a 5 µm CN phase
- Detection system: photo diode array (PDA)
MOBILE PHASES
- Type: methanol:water (55:45)
- Experiments with additives carried out on separate columns: no
- pH: 2.00 and 10.02
- Solutes for dissolving test and reference substances: All substances injected onto the HPLC were dissolved in the mobile phase.
DETERMINATION OF DEAD TIME
- Method: by means of homologous series
REFERENCE SUBSTANCES
Acetanilide, Atrazin, Isoproturon, Linuron, Naphthalene, 1,2,3-Trichlorobenzene, Fenthion, Phenanthrene, p,p-DDT - all present at a concentration of 20 mg/l.
DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: 100 µl
- Quantity of reference substances: 100 µl
- Intervals of calibration: at least once daily
REPETITIONS
- Number of determinations: 2
EVALUATION
- Calculation of capacity factors k': The capacity factor was determined using the calculation below:
K' = (tr - to)/to
Where:
k' = capacity factor
tr = retention time of the test substance
to = column dead time (retention time of an inert substance)
- Calculation of retention times: retention time measured in seconds
- Determination of the log Koc value:Koc calculated using the calibration curve (Please refer to Attachment 1)
Batch equilibrium or other method
- Computational methods:
- Not applicable
Results and discussion
Adsorption coefficientopen allclose all
- Type:
- Koc
- Value:
- 1 995.26
- Type:
- log Koc
- Value:
- 3.3
Results: HPLC method
- Details on results (HPLC method):
- - Retention times of reference substances used for calibration:
Please refer to Attachment 2
- Details of fitted regression line (log k' vs. log Koc): Please refer to Attachment 1
- Graph of regression line attached: Yes
- Average retention data for test substance:
pH 2 = 237 seconds
pH 10 = 71 seconds
Results: Batch equilibrium or other method
- Transformation products:
- no
- Statistics:
- Not applicable
Any other information on results incl. tables
From the experimetally dervied k' measurements and the literature Koc values of the reference substances, the equation of the fitted regression line was determined as:
log10 koc = a.log10 k' + b
where at pH 2, a = 5.11 and b = 2.18 and at pH 10 a = 7.38 and b = 2.16. The coefficient of determination (r2) of these data was calculated as 0.953 and 0.944 at pH2 and pH10, respectively, indicating a linear relationship between log10 Koc and log10 k'.
At pH 2 the log10 k' for S178207 was 0.220, therefore, the estimated log10 Koc for S178207 is 3.30. At pH 10 the log10 koc for S178207 could not be calculated and the estimated log10 Koc is therefore <1.5.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- The test described has been validated for the quantitative estimation of log10 koc values in the range 1.5 to 5.0. In those instances where the statistical treatment of the experimental data produces a calculated log10 koc value outside this range then th
- Conclusions:
- The log10 Koc at pH 2 has been determined to be 3.30 and at pH 10 it has been determined to be less than 1.5.
- Executive summary:
The guideline followed was OECD 121 Estimation of the Adsorption Coefficient (Koc) on Soil and Sewage Sludge using High Performance Liquid Chromatography (HPLC).
The log10 Koc at pH 2 has been determined to be 3.30 and at pH 10 it has been determined to be less than 1.5.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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