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EC number: 942-932-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation: The skin irritation
potential of the test substance was determined in a study equivalent to
OECD guideline 404. The test item showed skin corrosive effects.
Eye irritation: The eye irritation potential of the test item was
determined in a study equivalent to OECD guideline 405. Severe eye
damaging effects cat 1 were observed on one animal.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- no observation period of 14 days, no subdivision of the scores after 72 hours
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- no data
- Type of coverage:
- occlusive
- Preparation of test site:
- other: abraded and intact skin
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 mL
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 72 hours
- Number of animals:
- 12 animals
6 animals intact skin
6 animals abraded skin - Details on study design:
- TEST SITE
- Area of exposure: 1 inch x 1 inch
- Type of wrap if used: The patches are fixed to the application site by means of adhesive tape and the entire trunk of the rabbits is wrapped with an impervious material to maintain the test patches in position and to retard evaporation of volatile substances.
REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: 24 hours
SCORING SYSTEM: By the method of Draize - Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- animal 1
- Time point:
- 72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: intact skin
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- animal 2
- Time point:
- 72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: intact skin
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- animal 3
- Time point:
- 72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: intact skin
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- animal 4
- Time point:
- 72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: intact skin
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- animal 5
- Time point:
- 72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: intact skin
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- animal 6
- Time point:
- 72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: intact skin
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- animal 1
- Time point:
- 72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: abraded skin
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- animal 2
- Time point:
- 72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 h
- Remarks on result:
- other: abraded skin
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- animal 3
- Time point:
- 72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 h
- Remarks on result:
- other: abraded skin
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- animal 4
- Time point:
- 72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 h
- Remarks on result:
- other: abraded skin
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- animal 5
- Time point:
- 72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: abraded skin
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- animal 6
- Time point:
- 72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 h
- Remarks on result:
- other: abraded skin
- Irritation parameter:
- edema score
- Basis:
- animal: 1-6
- Time point:
- 24/48/72 h
- Remarks on result:
- other: an overall irritation score is provided only
- Irritation parameter:
- erythema score
- Basis:
- animal: 1-6
- Time point:
- 24/48/72 h
- Remarks on result:
- other: an overall irritation score is provided only
- Irritant / corrosive response data:
- After 24 hours, ischemia and slight to severe edema; after 72 hours, distinct or severe incrustation.
- Interpretation of results:
- Category 1C (corrosive) based on GHS criteria
- Conclusions:
- The skin irritation potential of the test substance was determined in a study equivalent to OECD guideline 404. The test item showed corrosive effects.
- Executive summary:
The skin irritation potential of the test item was determined in a study equivalent to OECD guideline 404. The test substance was applied undiluted in an amount of 0.5 mL. Six rabbits are treated on the intact skin, the other six on the abraded skin. The patches are fixed to the application site by means of adhesive tape and the entire trunk of the rabbits is wrapped with an impervious material to maintain the test patches in position and to retard evaporation of volatile substances. After an exposure period of 24 hours the patches were removed. The resulting skin reaction were read immediately after 24 hours and after 72 hours. The following scores are indicated as overall mean irritation scores after 72 hours. No subdivision was done for the scores after 72 hours:
Intact skin
Animal 1: 3
Animal 2: 3
Animal 3: 3
Animal 4: 3
Animal 5: 3
Animal 6: 4
Abraded skin
Animal 1: 3
Animal 2: 3
Animal 3: 4
Animal 4: 4
Animal 5: 4
Animal 6: 3
The test item showed skin corrosive effects. The effects were not reversibel after 72 h. After 24 hours, ischemia and slight to severe edema; after 72 hours, distinct or severe incrustation were observed.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- only one animal used
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- no data
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: other eye
- Amount / concentration applied:
- 1/10 mL
- Duration of treatment / exposure:
- Single treatment
- Observation period (in vivo):
- 21 days
- Number of animals or in vitro replicates:
- 1 rabbit
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: No washing
SCORING SYSTEM: According to Draize - Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- >= 2 - <= 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 21 d
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 21 d
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 21 d
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 21 d
- Irritant / corrosive response data:
- After 21 days the animals showed deformed eye-ball (ulcus cornea), moderate to severe corneal opacity, strongly vascularized fibroangioblastic tissue on cornea, iris and conjunctivae without visible damage.
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- The eye irritation potential of the test item was determined in a study equivalent to OECD guideline 405. Severe eye damaging effects were observed on one animal.
- Executive summary:
The eye irritation potential of the test item was determined in a study equivalent to OECD guideline 405. An amount of 1/10 mL of the test substance was applied undiluted to the eye of one rabbit. The other eye served as control eye. The eyes are not washed following instillation. The eye are examined at 24, 48, 72 hours, 7 days, 14 days and 21 days after instillation. The following results were determined (mean value 24, 48 and 72 h):
Scores of the animal examined
Cornea: 2 -3
Iris: 1
Conjunctivae: 3
Chemosis: 3
The effects were not reversible after 21 days. The test item showed severe eye damaging effects cat .1.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
The skin irritation potential of the test item was determined in a study equivalent to OECD guideline 404. The test substance was applied undiluted in an amount of 0.5 mL. Six rabbits are treated on the intact skin, the other six on the abraded skin. The patches are fixed to the application site by means of adhesive tape and the entire trunk of the rabbits is wrapped with an impervious material to maintain the test patches in position and to retard evaporation of volatile substances. After an exposure period of 24 hours the patches were removed. The resulting skin reaction were read immediately after 24 hours and after 72 hours. The following scores are indicated as overall mean irritation scores after 72 hours. No subdivision was done for the scores after 72 hours:
Intact skin
Animal 1: 3
Animal 2: 3
Animal 3: 3
Animal 4: 3
Animal 5: 3
Animal 6: 4
The test item showed skin corrosive effects. The effects were not reversibel after 72 h. After 24 hours, ischemia and slight to severe edema; after 72 hours, distinct or severe incrustation were observed.
Eye irritation
The eye irritation potential of the test item was determined in a study equivalent to OECD guideline 405. An amount of 1/10 mL of the test substance was applied undiluted to the eye of one rabbit. The other eye served as control eye. The eyes are not washed following instillation. The eye are examined at 24, 48, 72 hours, 7 days, 14 days and 21 days after instillation. The following results were determined (mean value 24, 48 and 72 h):
Scores of the animal examined
Cornea: 2 -3
Iris: 1
Conjunctivae: 3
Chemosis: 3
The effects were not reversible after 21 days. The test item showed severe eye damaging effects cat .1.
Justification for classification or non-classification
Eye irritation
Self-Classification, Labelling, and Packaging Regulation (EC) No 1272/2008
The available experimental test data is reliable and suitable for classification purposes under Regulation (EC) No 1272/2008. Based on the results the test substance is considered to be classified as eye damaging cat. 1 H318 under Regulation (EC) No 1272/2008.
Skin Irritation
Self-Classification, Labelling, and Packaging Regulation (EC) No 1272/2008
The available experimental test data is reliable and suitable for classification purposes under Regulation (EC) No 1272/2008. Based on the results the test substance is considered to be classified as skin corrosive cat. 1c H314 under Regulation (EC) No 1272/2008.
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