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Diss Factsheets
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EC number: 810-200-7 | CAS number: 1050477-45-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Flammability
Administrative data
Link to relevant study record(s)
- Endpoint:
- flammable solids
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- UN Manual of Tests and Criteria: Test N.1 (Test method for readily combustible solids)
- GLP compliance:
- no
- Other quality assurance:
- ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
- Specific details on test material used for the study:
- PPS sample number: 124089
- Test procedure:
- burning rate test: preliminary screening test
- Remarks on result:
- substance does not ignite and propagate combustion either by burning with flame or smouldering along 200 mm of the powder train within the 2 minutes test period
- Interpretation of results:
- not classified based on GHS criteria
- Conclusions:
- Carboxy-TH-naphthyridin is classified as a not readily combustible solid when tested according to UN-MTC Procedure N.1.
- Executive summary:
The test was performed as stipulated in UN test procedure ‘Recommendations on the Transport of Dangerous Goods - Manual of Tests and Criteria’ (UN-MTC), Part III, sub-section 33.2.1.4.1, Test N.1 ‘Test method for readily combustible solids’.
Carboxy-TH-naphthyridin was formed into a powder train about 250 mm long by 20 mm wide by 10 mm high on a non-combustible, non-porous and low heat-conducting base plate. 30 – 40 mm beyond the 100 mm timing zone, 1 mL of a wetting solution was added to the pile. A hot flame from a gas burner was applied to one end of the powder train until the powder ignites or for a maximum of 2 minutes. A preliminary screening test was performed to determine if propagation by burning with flame or smoldering occurs without wetted zone.
The substance in its delivery state was measured. The test substance melted when approached by the ignition flame. The substance did not burn up. No further testing was required.
Carboxy-TH-naphthyridin is classified as a not readily combustible solid when tested according to UN-MTC Procedure N.1.
- Endpoint:
- pyrophoric solids
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is known to be stable in contact with air at room temperature for prolonged periods of time (days) and hence, the classification procedure does not need to be applied
- Endpoint:
- self-heating substances / mixtures
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- UN Manual of Tests and Criteria: Test N.4 (Test method for self-heating substances)
- GLP compliance:
- no
- Other quality assurance:
- ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
- Specific details on test material used for the study:
- Sample: 122071
- Test procedure:
- 25 mm sample cube at 140°C
- Max. temp. reached:
- 158
- Result:
- negative outcome (no effect observed)
- Remarks:
- a brown melt remained in the basket
- Test procedure:
- other: 25 mm sample cube at 123 °C
- Max. temp. reached:
- 125
- Result:
- negative outcome (no effect observed)
- Test procedure:
- other: 50 mm sample cube 119 °C
- Max. temp. reached:
- 119
- Result:
- negative outcome (no effect observed)
- Test procedure:
- other: 100 mm sample cube at 108 °C
- Max. temp. reached:
- 113
- Result:
- negative outcome (no effect observed)
- Test procedure:
- other: 125 mm sample cube at 106 °C
- Max. temp. reached:
- 195
- Result:
- positive outcome (effect observed)
- Interpretation of results:
- not classified based on GHS criteria
- Conclusions:
- Extrapolation of the received values shows that the critical temperature of the substance for self-heating in volumes of 27 m^3 is distinct above 50 °C. Thus, Carboxy-TH-naphthyridin is not classified as self-heating substance.
- Executive summary:
According to UN N. 4, a Bowes-Cameron-Cage-Test was performed: Carboxy-TH-naphthyridin was filled in a basket (16 mL) and stored in a drying oven at a constant temperature of 140 °C for at least 24 h.
Afterwards, a volume dependent heat storage was perfomed:
The substance was filled in a basket and kept in a drying oven. The temperature was increased gradually until a visible exothermic effect occured. The sample temperatur was measured by a thermal element. As reference temperature a thermal element was in the headspace ot the drying oven. During the procedure the temperature was recorded computer based.
Extrapolation of the received values shows that the critical temperature of the substance for self-heating in volumes of 27 m^3 is distinct above 50 °C. Thus, Carboxy-TH-naphthyridin is not classified as self-heating substance.
- Endpoint:
- substances / mixtures which in contact with water emit flammable gases
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the organic substance does not contain metals or metalloids and hence, the classification procedure does not need to be applied
Referenceopen allclose all
The test substance melted when approached by the ignition flame.
Extrapolation shows that critical temperature of the substance for self-heating in volumes of 27 m^3 is distinct above 50 °C.
Description of key information
a) flammability: Carboxy-TH-naphthyridin is classified as a not readily combustible solid when tested according to UN-MTC Procedure N.1.
b) pyrophoric properties: Carboxy-TH-naphthyridin is known to be stable in contact with air at room temperature for prolonged periods of time.
c) self-heating: Extrapolation of the received values shows that the critical temperature of the substance for self-heating in volumes of 27 m^3 is distinct above 50 °C. Thus, Carboxy-TH-naphthyridin is not classified as self-heating substance.
d) contact with water: Carboxy-TH-naphthyridin does not contain metals or metalloids and hence, the classification procedure does not need to be applied.
Key value for chemical safety assessment
- Flammability:
- not classified
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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