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EC number: 246-467-6 | CAS number: 24801-88-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 August 1994
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- The restrictions were (i) scoring of animals not provided (ii) occlusive patch used (semi-occlusive recommended).
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- (scoring of animals not provided; occlusive patch used (semi-occlusive recommended))
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.4470 (Acute Dermal Irritation)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Triethoxy(3-isocyanatopropyl)silane
- EC Number:
- 246-467-6
- EC Name:
- Triethoxy(3-isocyanatopropyl)silane
- Cas Number:
- 24801-88-5
- Molecular formula:
- C10H21NO4Si
- IUPAC Name:
- triethoxy(3-isocyanatopropyl)silane
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: HRP, Inc., Denver, PA
- Age at study initiation: ~ 13 to 18 weeks
- Weight at study initiation: 2.0 to 3.5 kg
- Housing: no data available
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 61 to 70 °F [16-21 °C]
- Humidity (%): 40 to 70%
- Air changes (per hr): at least 10
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: ~ 1 April 1994 To: 6 May 1994
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml
- Concentration (if solution): undiluted - Duration of treatment / exposure:
- 3 minutes or 1 hour
- Observation period:
- 14 days (reading at 1, 24, 48 and 72 hours, and at 7 and 14 days)
- Number of animals:
- 1/sex given 1-hour treatment
3/sex given 3-minute treatment - Details on study design:
- TEST SITE
- Area of exposure: 1-inch square (~6 cm2)
- % coverage: no data available
- Type of wrap if used: gauze patch secured by adhesive tape, and polyethylene sheet around trunk
REMOVAL OF TEST SUBSTANCE
- Washing (if done): not performed
SCORING SYSTEM:
As per OECD guideline 404
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- 1-hour exposure period
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 4
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Remarks:
- 1-hour exposure period
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 3.6
- Max. score:
- 4
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Remarks:
- 1-hour exposure period
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Remarks:
- 3-minute exposure
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2.33
- Max. score:
- 4
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Remarks:
- 3-minute exposure
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Remarks:
- 3-minute exposure
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Remarks:
- 3-minute exposure
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 3.6
- Max. score:
- 4
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Remarks:
- 3-minute exposure
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 3.33
- Max. score:
- 4
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Remarks:
- 3-minute exposure
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 2.33
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Remarks:
- 3-minute exposure
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Remarks:
- 3-minute exposure
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 3.6
- Max. score:
- 4
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Remarks:
- 3-minute exposure
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 4
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Remarks:
- 3-minute exposure
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 3.3
- Max. score:
- 4
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Remarks:
- 3-minute exposure
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 3.6
- Max. score:
- 4
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Remarks:
- 3-minute exposure
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 3.6
- Max. score:
- 4
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- After three minutes of contact, severe oedema was seen in all rabbits 1 to 24 hours after exposure. Moderate to severe oedema was observed between 1 and 48 hours. Two rabbits developed superficial necrosis by one hour, and the remaining developed superficial necrosis by day 14. All rabbits developed ecchymoses by 72 hours, which subsided by day 14. All rabbits had desquamation and 5/6 had alopecia by day 14. Also observed were tan discolouration (3/6 rabbits by day 7), fissures (4/6 rabbits by day 14) and scab formation (1 rabbit at day 14).
After one hour of contact, severe oedema with moderate erythema was seen in both rabbits within the first hour of exposure. Erythema was severe within 48 hours. Ecchymoses were observed in both rabbits at 24 and 48 hours. Superficial necrosis and fissures were apparent on both rabbits by day 7. By day 9, superficial necrosis progressed to full thickness necrosis on the female rabbit. Necrosis persisted for 14 days in both rabbits. Desquamation, scabs and alopecia were observed on each animal on day 14.
Any other information on results incl. tables
The test material was clearly corrosive based on the description given.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Conclusions:
- In a GLP study performed according to OECD Test Guideline 404, undiluted triethoxy(3-isocyanatopropyl)silane was corrosive to the skin of rabbits when applied for one hour.
- Executive summary:
In an acute dermal irritation/corrosion study carried out to GLP and according to OECD Test Guideline 404, rabbits were exposed dermally to triethoxy(3-isocyanatopropyl)silane.
0.5 ml undiluted triethoxy(3-isocyanatopropyl)silane was applied under occlusion to the clipped, intact skin of groups of rabbits for three minutes (3 animals/sex) or for one hour (1 animal/sex). Animals were then observed at 1, 24, 48 and 72 hours, and at 7 and 14 days.
Moderate to severe irritation were seen after 1-48 hours in all rabbits given three-minute applications. Superficial necrosis was seen in two animals after 2 hours and in all six by 14 days; it did not develop to full thickness necrosis. Other effects included alopecia, tan discolouration, fissures and scab formation. Hour-long treatments resulted in severe irritation, including severe erythema and ecchymoses [haemorrhagic spots], in both animals by 48 hours. Superficial necrosis and fissures were present in both rabbits by day 7 and developed to full thickness necrosis in one rabbit by 14 days. Desquamation, scabs and alopecia were seen in both animals at 14 days.
Under these experimental conditions, undiluted triethoxy(3-isocyanatopropyl)silane was corrosive to the skin of rabbits when applied for one hour.
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