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Diss Factsheets
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EC number: 236-882-0 | CAS number: 13531-52-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The test substance is corrosive to the skin and detoriates eye mucous membranes. (BASF, 1977)
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976 - 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- Principles of method if other than guideline:
- BASF Test, see details in remarks on material and methods
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: male: 3.42 kg; male: 2.75 kg
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin of the same animals served as control.
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 1 mL - Duration of treatment / exposure:
- 20 h
- Observation period:
- 2 days
- Number of animals:
- 2
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm - Irritation parameter:
- other: Necrosis in all 2 animals after 1 min, 5 min, 15 min or 20 hours treatment
- Basis:
- mean
- Time point:
- other: 24 h
- Reversibility:
- not reversible
- Remarks on result:
- other: Both animals died 2 days after exposure.
- Irritant / corrosive response data:
- Based on the necrosis observed 24 hours after 1 min, 5 min, 15 min or 20 min treatment, the test substance is corrosive to the rabbit skin and should be classified according to the EU (R35) and to GHS (Cat 1A).
- Other effects:
- All 2 animals died within 2 days.
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Cat 1A Criteria used for interpretation of results: OECD GHS
Reference
Both animals died 2 days after exposure. Based on corrosive effects, the substance has to be judged as corrosive to skin.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976 - 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- 0.05 ml of intilled test substance
- Principles of method if other than guideline:
- BASF-Test, see details in remarks on material and methods.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: male: 2.71 kg; male: 3.32 kg - Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The adjacent eye served as saline control.
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.05 mL - Duration of treatment / exposure:
- 8 days
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 2
- Details on study design:
- REMOVAL OF TEST SUBSTANCE: no
SCORING SYSTEM: similar to OECD
TOOL USED TO ASSESS SCORE: hand-slit lamp - Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 1h-8 days
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 1h-8 days
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- not reversible
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 1h-24h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritant / corrosive response data:
- The test substance caused irreversible effects under the conditions of the study.
- Other effects:
- Necrosis, staphyloma were also observable and not reversible.
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Remarks:
- Migrated information
Reference
Time | Animal | Erythema | Opacity | Chemosis |
1h | No 1 | - | 3 | 2 |
No 2 | - | 2 | 1 | |
24 h | No 1 | 2 | 3 | 2 |
No 2 | 2 | 3 | 2 | |
8 days | No 1 | - | - | - |
No 2 | 2 | 4 | 2 |
The original BASF grading was converted into the numerical grading according to the OECD Draize system.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
With regard to the key study, the test substance was identified as corrosive dependent on the applied criteria. The corrosive potential was measured by applying 1 mL undiluted test substance: two rabbits were treated for 1, 5, 15 min or 20 h using occlusive conditions. An application site of 2.5 x 2.5 cm was covered with the liquid test substance. Both animals died 2 days after exposure. Based on corrosive effects, the substance has to be judged as corrosive to skin (BASF, 1977).
Eye irritation
Eye injury in rabbits was reported in an in-house study classified as key study (BASF, 1977), one drop of undiluted test substance in rabbit eyes caused irreversible effects of the eye mucous membranes within 24 h (oedema, opacity, staphyloma and necrosis), even after 1 h (oedema, opacity).
Justification for selection of skin irritation / corrosion endpoint:
Only one study available with the test substance. Estimated Klimisch Rating: 2
Justification for selection of eye irritation endpoint:
Only one study available with the test substance. Estimated Klimisch Rating: 2
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
Based on the results for skin irritation (corrosive) and for eye irritation, the test substance is classified for skin irritation/corrosion as follows:
Classification, Labelling, and Packaging Regulation (EC) No 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation 1272/2008 (CLP). As a result the substance is considered to be classified for skin or eye irritation under Regulation (EC) No 1272/2008, as amended for the sixth time in Regulation (EC) No 605/2014, as follows:
Cat. 1A, H314, causes severe skin burns and eye damage; Cat. 1, H318, causes serious eye damage.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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