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Diss Factsheets
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EC number: 205-275-2 | CAS number: 137-05-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study meets generally accepted scientific principles, but was not conducted in compliance with GLP or an OECD testing guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- no
- Remarks:
- prior to GLP
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Mecrilate
- EC Number:
- 205-275-2
- EC Name:
- Mecrilate
- Cas Number:
- 137-05-3
- Molecular formula:
- C5H5NO2
- IUPAC Name:
- methyl 2-cyanoprop-2-enoate
- Details on test material:
- - Name(s): Methyl 2-cyanoacrylate, Mecrilate, 2-Propenoic acid, 2-cyano-, methyl ester
- CAS 137-05-3
- Appearance: clear, colorless glue
- Purity: 88.8%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Albino
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- 6 male albino rats fasted for 18 hours prior to dosing.
The initial body weights ranged from 195 to 221 grams.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- The animals were observed during the day of dosing and daily thereafter for 14 days.
Decedents during the study were examined for gross lesions. - Statistics:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 4 440 mg/kg bw
- Based on:
- act. ingr.
- Remarks on result:
- other: 88.8 % ai
- Mortality:
- None (0/6)
- Clinical signs:
- other: Pilo-erection, lethargy
- Gross pathology:
- Caecum slightly enlarged , blood vessels of stomach, caecum and intestines were injected; large hardened mass of the test material of approximately the same size and shape of the stomach was found in the stomach of each animal sacrificed. However, no ulcers were observed in the stomach.
- Other findings:
- None
Any other information on results incl. tables
RESULTS
Onset of signs (S):
0 - 4 h |
4 - 8 h |
8 - 24 h |
6 S |
- |
- |
Mortaliy (M) and Recovery (R):
day 2 |
day 3 |
day 4 |
day 5 |
day 6 |
days 7 - 14 |
- |
- |
- |
3 R |
3 R |
- |
Caecum slightly enlarged, blood vessels of stomach. caecum and intestines were injected; large hardened mass of the test material of approximately the same size and shape of the stomach was found in the stomach of each animal sacrificed, however, no ulcers were observed in the stomach and no loss of body weight occurred in any of the animals during the 14-day period of observation.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 was found to be greater than 5000 mg/kg bw (greater than 4400 mg/kg bw relating to methyl 2-cyanoacrylate). In conclusion, the test material can be considered as practically nontoxic.
- Executive summary:
In a limit test with 6 male Albino rats, 5000 mg/kg bw of the Loctite glue "150 Super Bonder" was administered by gavage. All animals exhibited signs of intoxication (pilo-erection, lethargy), which were reversible within 5-6 days. No mortality was observed during the 14 -day observation period. Therefore, the LD50 for the tested material has been identified as > 5000 mg/kg bw (corresponding to 4400 mg/kg of the active ingredient methyl 2 -cyanoacrylate).
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