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EC number: 429-900-5 | CAS number: 82356-51-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 1991-07-18 to 1991-08-01
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Study performed according to OECD test guideline No. 402 and in compliance with GLP with acceptable restrictions: the % area exposed is not mentioned.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- 1981
- Deviations:
- yes
- Remarks:
- % area exposed not mentioned
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Inspected on 19 June 1990. Signed on 5 October 1990.
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- (5E)-3-Methyl-5-cyclopentadecen-1-one
- Cas Number:
- 101151-17-1
- Molecular formula:
- C16 H28 O
- IUPAC Name:
- (5E)-3-Methyl-5-cyclopentadecen-1-one
- Reference substance name:
- (5Z)-3-Methyl-5-cyclopentadecen-1-one
- Cas Number:
- 21944-94-5
- Molecular formula:
- C16 H28 O
- IUPAC Name:
- (5Z)-3-Methyl-5-cyclopentadecen-1-one
- Reference substance name:
- (4E)-3-Methyl-4-cyclopentadecen-1-one
- Cas Number:
- 62221-84-5
- Molecular formula:
- C16 H28 O
- IUPAC Name:
- (4E)-3-Methyl-4-cyclopentadecen-1-one
- Test material form:
- liquid
- Details on test material:
- - Physical state: colourless liquid
- Reception date: 1991-06-27
- Storage condition of test material: in the dark at about 4°C
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD(SD)BR strain (VAF plus)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River (UK) Limited, Margate Kent
- Age at study initiation: 10-11 weeks
- Weight at study initiation: M: 249-266 g; F:230-245g
- Fasting period before study: no
- Housing: individually housed in grid bottomed cages suspended over cardboard lined excreta trays.
- Diet (e.g. ad libitum): pelleted rodent diet ad libitum (SQC Rat and Mouse Maintenance Diet No. 1 Expanded, produced by Special Diets Services, Witham, Essex)
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 6 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-22 °C
- Humidity (%): 55-65 %
- Air changes (per hr): no data
- Photoperiod: 12 hrs dark / 12 hrs light
IN-LIFE DATES: no data
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: no data
- Type of wrap if used: pad of surgical gauze 4 plies thick overlaid with a strip of aluminium foil and secured in position by a length of 5.0 cm wide 'Elastoplast' elastic adhesive bandage.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): gentle swabbing with cotton wool soaked in warm water
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2 mL/kg bw - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 animals/sex/dose
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
Clinical signs: approximately 30 minutes, 1, 2 and 4 hours afters dosing and thereafter for 14 consecutive days.
Weighing: on the day of dosing, on days 8 and 15.
- Necropsy of survivors performed: yes, including opening of the thoracic, abdominal and visceral cavities, and examination of the major organs. Abnormal tissues and organs were preserved in buffered formol saline. - Statistics:
- none
Results and discussion
- Preliminary study:
- not applicable
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- >= 2 000 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occurred during the study.
- Clinical signs:
- other: Peri-nasal staining was noted in most animals, onset and recovery occurring earlier in males than in females. Piloerection was also observed in 4 males and 1 female, lasting from one to 5 days.
- Gross pathology:
- The necropsy findings were consistent with the background macroscopic pathology of this strain of rats:
- Thyroid: reddened appearance in 1 animal (1M)
- Thymus: reddened appearance in 4 animals (2M, 2F)
- Urinary bladder: distended with fluid in 1M and contained white waxy plug in 3M - Other findings:
- None
Any other information on results incl. tables
no other information
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Dermal LD50Combined > 2000 mg/kg bw
- Executive summary:
In a limit acute dermal toxicity study performed according to the OECD guideline No. 402 and in compliance with GLP, groups of young adult Crl:CD(SD) rats (5/sex) were occlusively exposed to undiluted test material for 24 hours at dose of 2000 mg/kg bw. The animals were observed for mortality, clinical signs including dermal reactions and body weight for 14 days and then necropsied for macroscopic observations.
No mortality occurred during the study. There was no adverse effect on bodyweight gain.
Peri-nasal staining was noted in most animals, onset and recovery occurring earlier in males than in females. Piloerection was also observed in 4 males and 1 female, lasting from one to 5 days. These effects, considered as mild, were fully reversible. Therefore the test material was considered to be essentially non-toxic at 2000 mg/kg bw.
Dermal LD50Combined > 2000 mg/kg bw
Under the test conditions, the test material is not classified according to the Regulation EC No. 1272/2008 (CLP) and to the GHS.
This study is considered as acceptable and satisfies the requirement for acute dermal toxicity endpoint.
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