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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
29 Mar - 06 Apr 2009
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2009
Report date:
2009

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
Version / remarks:
OECD 404
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
sukls28108/2009

Test material

Constituent 1
Chemical structure
Reference substance name:
Reaction products of acetic acid and acetylferrocene and butan-1-ol and 2-methylpropan-1-ol and propan-1-ol and propan-2-ol
EC Number:
700-283-7
Molecular formula:
Exact molecular formula is not known as it is a reaction mass. Empiric formula: C5H5FeC5H4COCmHn
IUPAC Name:
Reaction products of acetic acid and acetylferrocene and butan-1-ol and 2-methylpropan-1-ol and propan-1-ol and propan-2-ol
Details on test material:
According to INQ-C-0000036278-61-01, INQ-C-0000036386-62-01, and INQ_RESULT_INQ-C-0000036417-65-01 from ECHA, identification of a substance has been changed to UVCB substance. Name of the substance on the study results is the old name (reaction mass of butan-1-ol and propan-2-ol, ReduxCo), however these reports should be regarded valid as all studies were performed on the substance that is being registered - ReduxCo.

Test animals

Species:
rabbit
Strain:
New Zealand Red

Test system

Type of coverage:
semiocclusive
Preparation of test site:
shaved
Vehicle:
not specified
Controls:
not required
Duration of treatment / exposure:
4 hours
Observation period:
rabbits were examined for signs of erythema and oedema at 1, 24, 48 and 72 hours after patch removal.
Number of animals:
3 female animals

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal: 1, 2, 3
Time point:
other: 72h
Score:
0
Max. score:
4
Reversibility:
no data
Irritation parameter:
edema score
Basis:
animal: 1, 2, 3
Time point:
other: 72 h
Score:
0
Max. score:
4
Reversibility:
no data
Other effects:
no erythema and no oedema were observed during experiment.

Any other information on results incl. tables

there was no evidence of a corrosive effect on the skin.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The test substance ReduzCo was tested for acute dermal irritation/corrosion.
Three rabbits were exposed to 0.5 ml of test substance, applied onto clipped skin for 4 hours using a semi-occlusive dressing. Skin reactions were evaluated after patch removal and observations were made at 1, 24, 48, 72 hours after exposure. No evidence of a corrosive effect or symptoms of irritation were observed in the skin.
Executive summary:

No symptoms of sysyemic toxicity were observed in the animals during the test period.

No skin irritation was caused by 4 -hour exposure to ReduxCo.

Not classified as irritating/corrosive.