Registration Dossier
Registration Dossier
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EC number: 200-315-5 | CAS number: 57-13-6
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics, other
- Type of information:
- experimental study
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Urea. CAS No. 57-13-6
- Author:
- OECD SIDS (Organisation for Economic Co-operation and Development Screening Information Data Set)
- Year:
- 2 002
- Bibliographic source:
- https://hpvchemicals.oecd.org/UI/handler.axd?id=89564308-0887-4614-8a20-e542ce76221a
Materials and methods
- Objective of study:
- other: excretion in urine and sweat; blood concentration of endogenous urea
- Principles of method if other than guideline:
- - Parameters analysed / observed: excretion urea in urine and sweat; concentration urea in blood
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Urea
- EC Number:
- 200-315-5
- EC Name:
- Urea
- Cas Number:
- 57-13-6
- Molecular formula:
- CH4N2O
- IUPAC Name:
- urea
- Details on test material:
- It is assumed that the purity is 100%
Constituent 1
Test animals
- Species:
- other: human adult
Administration / exposure
- Route of administration:
- other: endogeneous urea
- Details on study design:
- Physiological concentrations in man were determined.
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on distribution in tissues:
- The blood concentration of urea is also relatively high, 3.3-6.7 mmol/L (200-500 mg/L)
- Details on excretion:
- Urea is an endogenous product of protein and amino acid catabolism, and consequently 20-35g (200-500 mg/kg body weight/day) of urea is excreted daily in human urine, in sweat 120-570 mg/L.
Applicant's summary and conclusion
- Conclusions:
- Urea is an endogenous product of protein and amino acid catabolism. Concentrations of endogenous urea in adult human are as follows:
In urine 20-35 g/24h (200-500 mg/kg body weight/day)
In sweat 120-570 mg/L
In blood 3.3-6.7 mmol/L (200-500 mg/L). - Executive summary:
Urea is an endogenous product of protein and amino acid catabolism. Concentrations of endogenous urea in adult human are as follows:
In urine 20-35 g/24h (200-500 mg/kg body weight/day)
In sweat 120-570 mg/L
In blood 3.3-6.7 mmol/L (200-500 mg/L).
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