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Diss Factsheets
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EC number: 700-490-2 | CAS number: 36635-56-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
Test material
- Reference substance name:
- N-[[(4-methylphenyl)sulfonyl]methyl]formamide
- EC Number:
- 700-490-2
- Cas Number:
- 36635-56-0
- Molecular formula:
- C9H11NO3S
- IUPAC Name:
- N-[[(4-methylphenyl)sulfonyl]methyl]formamide
- Details on test material:
- - Name of test material (as cited in study report): CGA 224433 tech.
- Physical state: solid
- Analytical purity: 100%
- Lot/batch No.: P.709027
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Initial body weight range: 214 - 255g
- Fasting period before study: overnight
- Housing: Macrolon cages type 3, std soft wood bedding
- Diet (e.g. ad libitum): NAFAG 890 Tox ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 2°C
- Humidity (%): 55 +/- 10%
- Air changes (per hr): 15 air changes per hour
- Photoperiod (hrs dark / hrs light): 12hour/day light cycle
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- arachis oil
- Details on dermal exposure:
- TEST SITE
- Area of exposure: back
- % coverage: at least 10%
REMOVAL OF TEST SUBSTANCE
- Washing (if done): with lukewarm water
- Time after start of exposure: 24hrs
VEHICLE
- Amount(s) applied (volume or weight with unit): 4ml/kg bw - Duration of exposure:
- 24hrs
- Doses:
- 200mg/kg single dose
- No. of animals per sex per dose:
- 5 animals per sex per dose
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily observation and weighing at start, day 7 and day 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology - Statistics:
- From the body weights, the group means and their standard deviations were calculated
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortalities occured during this test
- Clinical signs:
- Piloerection, dyspnea and abnormal body postures were seen, being common symptoms in acute tests.
- Body weight:
- Recorded before exposure and at days 7 and 14
weight development within expected limits - Gross pathology:
- All animals submitted to necropsy - no deviations from normal morphology were observed.
Applicant's summary and conclusion
- Interpretation of results:
- relatively harmless
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Upon single dose dermal application and a 14 day post treatment observation period, no mortalities occured, all animals recovered within 10 days and no deviations noted during autopsy.
CGA 224433 tech. is therefore deemed to be relatively harmless under test conditions. - Executive summary:
Based upon the results in this test it has been concluded that the following LD50 (with 95% confidnce limits calculated where possible) was determined for CGA 224433 tech.
LD50 male = greater than 2000mg/kg bw
LD50 female = greater than 2000mg/kg bw
LD50 both sexes = greater than 2000mg/kg bw
Thus is can be concluded that no hazard classification is required for acute dermal toxicity
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