Registration Dossier
Registration Dossier
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EC number: 203-672-5 | CAS number: 109-43-3
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Short summary of results; russian translation
Data source
Reference
- Reference Type:
- publication
- Title:
- No information
- Author:
- Astapova, S.A. et al.
- Year:
- 1 990
- Bibliographic source:
- Gigiena i sanitarija 55: 86
Materials and methods
- Principles of method if other than guideline:
- Rats are continuously exposed to vapours of the test substance for 24h/day over a period of 4 months.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Dibutyl sebacate
- EC Number:
- 203-672-5
- EC Name:
- Dibutyl sebacate
- Cas Number:
- 109-43-3
- Molecular formula:
- C18H34O4
- IUPAC Name:
- dibutyl sebacate
- Details on test material:
- - Name of test material (as cited in study report): DBS
- Analytical purit: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Duration of treatment / exposure:
- 24 h/day, 7 days/week; over a period of 4 months
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.07 ± 0.004, 0.63 ± 0.021 and 6.2 ± 0.25 mg/m³
Basis:
analytical conc.
- No. of animals per sex per dose:
- no data
Results and discussion
Effect levels
- Dose descriptor:
- other: LIMac
- Effect level:
- 0.63 mg/m³ air (analytical)
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: LIMac: threshold for acute effects
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
barriere change of neuromuscular stimulation: LIMac = 0.9 mg/m³
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
