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Diss Factsheets
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EC number: 247-660-8 | CAS number: 26401-35-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to fish, other
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2021
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- 1. SOFTWARE: Ecosar Application
2. MODEL: ECOSAR v2.0
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL: representative structure: CC(C)CCCCCCCCCCOC(=O)CCCCC(=O)OCCCCCCCCCCC(C)C; measured water solubility 0.0007 mg/L; measured log Kow 11.7
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL: see attached justification documents
5. APPLICABILITY DOMAIN: see attached justification documents
6. ADEQUACY OF THE RESULT: As indicated in the attached methodology document, in the development of the ECOSAR equations for neutral organics and classes with excess toxicity, the training sets generally include chemicals with log Kow values in the range of -3 to 8 and molecular weights less than 1000. However, the domain of the model is considered to be larger than the descriptor range of the training set of chemicals. Although the individual equations may not have been not built using chemicals with log Kow values greater than 5.0 (acute) and 8.0 (chronic), the model can still make accurate qualitative determination of potential toxicity under environmental conditions for chemicals outside the log Kow descriptor domain. As such, the prediction fits the purpose of classification and labelling and risk assessment. - Principles of method if other than guideline:
- see fields 'Justification for type of information' and 'Attached justification'
- GLP compliance:
- no
- Total exposure duration:
- 33 d
- Key result
- Duration:
- 33 d
- Dose descriptor:
- NOEC
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- other: growth
- Remarks on result:
- other: no effects up to limit of solubility predicted
- Conclusions:
- No effects are estimated in saturated solutions even with long-term exposures.
- Executive summary:
Long-term aquatic toxicity was estimated using the ECOSAR model (applicability explained in the attached reports). No toxic effects are expected to occur in saturated solutions even with long-term exposures.
This is consistent with toxicity test results for similar C-8 and C10 trimellitate compounds (tris-ethylhexyl trimellitate, EC #:222-020-0 and mixed decyl and octyl trimellitates , EC #:304-780-6) where no effects were observed at levels above solubility in standard long-term aquatic toxicity tests; as well as general literature for poorly soluble chemicals (Tolls et al. 2009).
Reference
Description of key information
No toxic effects are expected to occur in saturated solutions even with long-term exposures.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.