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EC number: 231-634-8 | CAS number: 7664-39-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987-06-23
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- ISO 8192 (Water quality - Test for inhibition of oxygen consumption by activated sludge for carbonaceous and ammonium oxidation)
- Version / remarks:
- 1986
- GLP compliance:
- no
- Specific details on test material used for the study:
- Sodium fluoride (termed Natriumfluorid in the test report)
- Analytical monitoring:
- no
- Remarks:
- (confirmatory analysis of exposure concentrations is not a requirement of the test method)
- Details on sampling:
- Not relevant
- Vehicle:
- no
- Remarks:
- Appropriate quantities of the test substance were weighed directly into the corresponding test vessels.
- Test organisms (species):
- activated sludge
- Details on inoculum:
- The activated sludge inoculum was obtained from a 3L laboratory simulation unit. The report does not state whether the unit was fed with settled domestic or synthetic sewage. The dry sludge solids concentration of the inoculum was 6 g/L and the inoculum was added in 25 mL aliquots to give a dry solids concentration of 600 mg/L in the final working volume of 250 mL in each of the biotic test vessels. The inoculum was withheld from a single vessel at the highest test substance concentration and served as an abiotic control against auto-oxidation.
- Test type:
- static
- Water media type:
- other: synthetic sewage prepared according to ISO 8192-1886 (E), section 4.2
- Limit test:
- no
- Total exposure duration:
- 3 h
- Post exposure observation period:
- After the 3h exposure and aeration phase, oxygen consumption was measured during intervals of between 1.0 and 10 minutes, depending on the rate of decline.
- Hardness:
- Not reported. Hardness was a function of the mineral composition of the synthetic sewage used in the test.
- Test temperature:
- 20.4 to 21.4°C
- pH:
- 7.9 to 8.3
- Dissolved oxygen:
- 2.40 to 8.70 mg O2/L (at the start of respiration rate measurements)
- Salinity:
- Not relevant
- Conductivity:
- Not reported
- Nominal and measured concentrations:
- The nominal test substance concentrations were 0 (control), 1000, 1800, 3200, 5600 and 10000 mg NaF/L.
- Details on test conditions:
- 3 hour incubation with activated sludge
- Reference substance (positive control):
- yes
- Remarks:
- 3,5-dichlorophenol (3,5-DCP)
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- 2 930 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks on result:
- other: Equivalent to 1324 mg F/L.
- Key result
- Duration:
- 3 h
- Dose descriptor:
- EC10
- Effect conc.:
- 1 127 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Remarks on result:
- other: Equivalent to 510 mg F/L
- Details on results:
- An EC10 of 1127 mg NaF/L is reported, equivalent to 509 mg fluoride/L.
- Results with reference substance (positive control):
- 0% inhibition at 1 mg 3,5-DCP/L
75% inhibition at 20 mg 3,5-DCP/L - Reported statistics and error estimates:
- The following values were determined by probit analysis:
EC05: 859 mg NaF/L (95% CL: 365 - 1289 mg NaF/L)
EC10: 1127 mg NaF/L (95% CL: 562 - 1586 mg NaF/L)
EC50: 2930 mg NaF/L (95% CL: 2270 - 3715 mg NaF/L)
EC90: 7620 mg NaF/L (95% CL: 5532 - 14444 mg NaF/L)
EC95: 9993 mg NaF/L (95% CL: 6821 - 22165 mg NaF/L) - Validity criteria fulfilled:
- yes
- Conclusions:
- An EC10 of 1127 mg NaF/L (510 mg fluoride-equivalent/L) is reported in a guideline-compliant ASRIT.
- Executive summary:
In an activated sludge respiration inhibition study performed according to ISO 8192-1986 (E) (analogous to OECD 209), the 3h EC10 of sodium fluoride was 1127 mg/L, equivalent to 510 mg fluoride/L.
- Endpoint:
- toxicity to microorganisms, other
- Remarks:
- Various endpoints investigating toxicity to microorganisms
- Type of information:
- other: review
- Adequacy of study:
- weight of evidence
- Study period:
- 16 to 72 hours
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- The EU RAR summarises and reviews the available data on the toxicity of fluoride to aquatic microorganisms. Methodologcial data for individual studies are incomplete, however the studies have been assessed as part of the EU RAR and are therefore considered to be suitabley reliable.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The EU RAR summairses a number of non-Guideline studies
- GLP compliance:
- no
- Analytical monitoring:
- not specified
- Test organisms (species):
- other: various
- Test type:
- static
- Water media type:
- freshwater
- Remarks on exposure duration:
- see details
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 83 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Remarks on result:
- other: Chilomonas paramaecium
- Remarks:
- (Bringmann and Kühn, 1981)
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 101 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Remarks on result:
- other: Entosiphon sulcatum
- Remarks:
- (Bringmann and Kühn, 1981)
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 180 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- other: inhibition of acid formation from glucose
- Remarks on result:
- other: Eschericia coli
- Remarks:
- (Bringmann and Kühn, 1981)
- Duration:
- 20 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 7.1 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Remarks on result:
- other: Uronema parduczi
- Remarks:
- (Bringmann and Kühn, 1981)
- Duration:
- 28 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 226 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- other: Inhibition of feed uptake
- Remarks on result:
- other: Microregma heterotoma
- Remarks:
- (Bringmann and Kühn, 1981)
- Duration:
- 16 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 231 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Remarks on result:
- other: Pseudomonas putida
- Remarks:
- (Bringmann and Kühn, 1981)
- Validity criteria fulfilled:
- not specified
- Conclusions:
- NOEC values of between 7.1 -226 mg/L are reported.
- Executive summary:
The EU RAR summarises and reviews the available data on the toxicity of fluoride to aquatic microorganisms; NOEC values of between 7.1 -226 mg/L are reported.
- Endpoint:
- toxicity to microorganisms, other
- Remarks:
- Various endpoints investigating toxicity to microorganisms
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- It is considered appropriate to address the toxicity to microorganisms data requirement for hydrogen fluoride (HF) by read-across to available data on sodium fluoride (NaF).
In water, HF (as hydrofluoric acid when in water) dissociates rapidly to form hydrogen (H+) and fluoride (F−) ions, whereas NaF (the highly soluble sodium salt of fluoride) will be fully hydrated in water as separate sodium (Na+) and F- ions. Both HF and NaF (as well as other fluorides) will therefore dissociate rapidly to form F- ions in the aquatic environment, with any effects observed being directly attributable to the F- ion. The Na+ ion is naturally occurring and regulated by organisms (i.e. by homeostatic mechanisms) and consequently is not considered to have an impact on the read-across of ecotoxicological data. On this basis, the profile of HF is comparable to that of NaF with respect to the environment. - Reason / purpose for cross-reference:
- read-across source
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 83 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Remarks on result:
- other: Chlomonas paramaecium
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 101 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Remarks on result:
- other: Entosiphon sulcatum
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 180 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- other: inhibition of acid formation from glucose
- Remarks on result:
- other: Eschericia coli
- Duration:
- 20 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 7.1 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Remarks on result:
- other: Uronema parduczi
- Duration:
- 28 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 226 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- other: Inhibition of feed uptake
- Remarks on result:
- other: Microregma heterotoma
- Duration:
- 16 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 231 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Remarks on result:
- other: Pseudomonas putida
- Validity criteria fulfilled:
- not specified
- Conclusions:
- NOEC values of between 7.1 -226 mg/L are reported.
- Executive summary:
It is considered appropriate to address the toxicity to microorganisms data requirement for hydrogen fluoride (HF) by read-across to available data on sodium fluoride (NaF). In water, HF (as hydrofluoric acid when in water) dissociates rapidly to form hydrogen (H+) and fluoride (F−) ions, whereas NaF (the highly soluble sodium salt of fluoride) will be fully hydrated in water as separate sodium (Na+) and F- ions. Both HF and NaF (as well as other fluorides) will therefore dissociate rapidly to form F- ions in the aquatic environment, with any effects observed being directly attributable to the F- ion. The Na+ ion is naturally occurring and regulated by organisms (i.e. by homeostatic mechanisms) and consequently is not considered to have an impact on the read-across of ecotoxicological data. On this basis, the profile of HF is comparable to that of NaF with respect to the environment.
The EU RAR summarises and reviews the available data on the toxicity of fluoride to aquatic microorganisms; NOEC values of between 7.1 -226 mg/L are reported.
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- It is considered appropriate to address the toxicity to microorganisms data requirement for hydrogen fluoride (HF) by read-across to available data on sodium fluoride (NaF).
In water, HF (as hydrofluoric acid when in water) dissociates rapidly to form hydrogen (H+) and fluoride (F−) ions, whereas NaF (the highly soluble sodium salt of fluoride) will be fully hydrated in water as separate sodium (Na+) and F- ions. Both HF and NaF (as well as other fluorides) will therefore dissociate rapidly to form F- ions in the aquatic environment, with any effects observed being directly attributable to the F- ion. The Na+ ion is naturally occurring and regulated by organisms (i.e. by homeostatic mechanisms) and consequently is not considered to have an impact on the read-across of ecotoxicological data. On this basis, the profile of HF is comparable to that of NaF with respect to the environment. - Reason / purpose for cross-reference:
- read-across source
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- 2 930 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks on result:
- other: Equivalent to 1324 mg F/L.
- Key result
- Duration:
- 3 h
- Dose descriptor:
- EC10
- Effect conc.:
- 1 127 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Remarks on result:
- other: Equivalent to 510 mg F/L
- Details on results:
- An EC10 of 1127 mg NaF/L is reported, equivalent to 509 mg fluoride/L.
- Results with reference substance (positive control):
- 0% inhibition at 1 mg 3,5-DCP/L
75% inhibition at 20 mg 3,5-DCP/L - Reported statistics and error estimates:
- The following values were determined by probit analysis:
EC05: 859 mg NaF/L (95% CL: 365 - 1289 mg NaF/L)
EC10: 1127 mg NaF/L (95% CL: 562 - 1586 mg NaF/L)
EC50: 2930 mg NaF/L (95% CL: 2270 - 3715 mg NaF/L)
EC90: 7620 mg NaF/L (95% CL: 5532 - 14444 mg NaF/L)
EC95: 9993 mg NaF/L (95% CL: 6821 - 22165 mg NaF/L) - Validity criteria fulfilled:
- yes
- Conclusions:
- An EC10 of 1127 mg NaF/L (510 mg fluoride-equivalent/L) is reported in a guideline-compliant ASRIT.
- Executive summary:
It is considered appropriate to address the toxicity to microorganisms data requirement for hydrogen fluoride (HF) by read-across to available data on sodium fluoride (NaF). In water, HF (as hydrofluoric acid when in water) dissociates rapidly to form hydrogen (H+) and fluoride (F−) ions, whereas NaF (the highly soluble sodium salt of fluoride) will be fully hydrated in water as separate sodium (Na+) and F- ions. Both HF and NaF (as well as other fluorides) will therefore dissociate rapidly to form F- ions in the aquatic environment, with any effects observed being directly attributable to the F-ion. The Na+ ion is naturally occurring and regulated by organisms (i.e. by homeostatic mechanisms) and consequently is not considered to have an impact on the read-across of ecotoxicological data. On this basis, the profile of HF is comparable to that of NaF with respect to the environment.
In an activated sludge respiration inhibition study performed according to ISO 8192-1986 (E) (analogous to OECD 209), the 3h EC10 of sodium fluoride was 1127 mg/L, equivalent to 510 mg fluoride/L.
Referenceopen allclose all
0%, 37.5%, 50.0%, 75.0% and 100% respiration inhibition was recorded at nominal concentrations of 1000, 1800, 3200, 5600 and 10000 mg NaF/L, respectively.
The EU RAR reports NOEC values of between 7.1 -226 mg/L.
The EU RAR reports NOEC values of between 7.1 -226 mg/L.
0%, 37.5%, 50.0%, 75.0% and 100% respiration inhibition was recorded at nominal concentrations of 1000, 1800, 3200, 5600 and 10000 mg NaF/L, respectively.
Description of key information
In an activated sludge respiration inhibition study performed according to ISO 8192-1986 (E) (analogous to OECD 209), the 3h EC10 and EC50 of sodium fluoride were 1127 mg/L and 2930 mg/L respectively, equivalent to 510 and 1324 mg fluoride/L. A number of supporting studies are reported in the EU RAR.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 1 324 mg/L
- EC10 or NOEC for microorganisms:
- 510 mg/L
Additional information
In an activated sludge respiration inhibition study performed according to ISO 8192-1986 (E) (analogous to OECD 209), the 3h EC10 and EC50 of sodium fluoride were 1127 mg/L and 2930 mg/L respectively, equivalent to 510 and 1324 mg fluoride/L. The EU RAR summarises and reviews the other available data on the toxicity of fluoride to aquatic microorganisms; NOEC values of between 7.1 -226 mg/L are reported.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.